¥1,737.73
请联系客服了解存货情况
推荐产品
生物来源
human coronary artery (normal, tunica intima and media)
质量水平
包装
pkg of 500,000 cells
制造商/商品名称
Cell Applications, Inc
生长模式
Adherent
核型
2n = 46
形态学
smooth muscle
技术
cell culture | mammalian: suitable
相关疾病
diabetes; stroke; cardiovascular diseases
运输
dry ice
相关类别
1 of 4
此商品 | A4414 | G2500 | C3400 |
|---|---|---|---|
| assay ≥70% protein basis (biuret) | assay ≥99% (agarose gel electrophoresis) | assay 70-90% (biuret) | assay 87-94% protein basis |
| biological source Porcine muscle | biological source Porcine | biological source Porcine skin | biological source bovine milk |
| technique(s) electrophoresis: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable |
| form lyophilized powder (contains Tris buffer salts) | form lyophilized powder | form powder | form powder |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - | storage temp. - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
一般描述
Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.
Human Coronary Artery Smooth Muscle Cells (HCASMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
HCASMC has been utilized in a number of research studies, for example, to:
Characterization: positive for smooth muscle cell specific alpha-actin expression.
Human Coronary Artery Smooth Muscle Cells (HCASMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
HCASMC has been utilized in a number of research studies, for example, to:
- Study signaling pathways regulating smooth muscle differentiation (Zhou, 2010); and chronic inflammation of arterial wall that leads to artherosclerosis (Kiyan, 2014)
- Demonstrate that STAT-1 and STAT-3 regulate VEGF production in smooth muscle cells by having opposing effects on HIF-1α expression (Albasanz-Puig, 2012); study the mechanisms of hypoxia and reoxigenation injuries in by demonstrating increased production of ROS and inflammatory cytokines, and further showing that DHA is not beneficial in this type of injuries (Feng, 2012)
- Investigate the gene expression differences between smooth muscle cells from different arteries, underlying their differential response to injuries and proliferation stimuli (Lange, 2013)
- Suggest the hypermethylation of SOCS3 gene as the connection between TNF-α and IGF-1 released in response to mechanical injury during coronary intervention, and the induction of cytokines leading to intimal hyperplasia and restenosis (Dhar, 2013)
- Develop a novel VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity (Fujita, 2013); and investigate novel therapies and drug combinations to achieve optimal target selectivity (Lehar, 2009; Wo-Wong, 2013)
- Develop elastic scaffolds for tissue engineering (Nivison-Smith, 2010, 2012) and novel treatment strategies to prevent stent restenosis by designing new materials (Crowder, 2012), or drug therapies to preferentially inhibit smooth muscle cell growth (O’Neill, 2009; Mociornita, 2013)
Characterization: positive for smooth muscle cell specific alpha-actin expression.
细胞系来源
Artery
应用
vascular research, supply of blood to heart muscle
组分
Basal Medium containing 10% FBS & 10% DMSO
制备说明
- 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 16 doublings
传代培养常规
Please refer to the HCASMC Culture Protocol.
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study.
Zekri-Nechar, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 19, 1-1 (2022)
Nesrine Bouhrira et al.
Fluids and barriers of the CNS, 19(1), 94-94 (2022-11-27)
Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demonstrated that altered shear stress exerted by disturbed flow disrupts
商品
Technical information for working with human coronary artery smooth muscle cells including thawing, subculturing and cryopreservation
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持
