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Y0001181

奥芬那君盐酸盐

Name: 奥芬那君 盐酸盐
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

β-二甲基氨基乙基-2-甲基二苯甲醚盐酸盐, N,N-二甲基-2-(2-甲基二苯甲基氧基)乙胺盐酸盐, 邻甲苯海明盐酸盐

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About This Item

经验公式（希尔记法）:

C₁₈H₂₃NO · HCl

CAS号:

341-69-5

分子量:

305.84

Beilstein:

3745818

MDL编号:

MFCD00012480

UNSPSC代码:

41116107

PubChem化学物质编号:

329831294

NACRES:

NA.24

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Y0000102

奥芬那君杂质E

Supelco

PHR1070

无水乙醇

Sigma-Aldrich

G8270

D -(+)-葡萄糖

USP

1181302

右旋糖

Sigma-Aldrich

158968

α-D-葡萄糖

Sigma-Aldrich

G7021

D -(+)-葡萄糖

Supelco

69479

N-甲基-N-（三甲基硅烷基）三氟乙酰胺

Sigma-Aldrich

H3128

钙羧酸

Sigma-Aldrich

A3795

硝酸铵

Supelco

PHR1372

甲醇

等级

pharmaceutical primary standard

API类

orphenadrine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

Cl.CN(C)CCOC(c1ccccc1)c2ccccc2C

InChI

1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H

InChI key

UQZKYYIKWZOKKD-UHFFFAOYSA-N

基因信息

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , HRH1(3269) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) , SLC6A2(6530)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Orphenadrine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

毒蕈碱型受体拮抗剂；H₁ 组胺受体拮抗剂；肌肉松弛剂。据报道，奥芬那君还可抑制去甲肾上素转运蛋白并且阻塞 NMDA 受体离子通道。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1479010

1479031

1479020

1479009

奥芬那君柠檬酸盐, United States Pharmacopeia (USP) Reference Standard

1479064

1479053

PHR1777

奥芬那君, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2957

PHR2958

PHR2959

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

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[Interaction of drugs with the primary disease - when medicines exacerbate illnesses].

Anne Taegtmeyer et al.

Praxis, 101(6), 363-370 (2012-03-16)

Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.

Eberhard P Scholz et al.

Naunyn-Schmiedeberg's archives of pharmacology, 376(4), 275-284 (2007-10-30)

The anticholinergic antiparkinson drug orphenadrine is an antagonist at central and peripheral muscarinic receptors. Orphenadrine intake has recently been linked to QT prolongation and Torsade-de-Pointes tachycardia. So far, inhibitory effects on I (Kr) or cloned HERG channels have not been

[Diclofenac/orphenadrine as a combined analgetic in post-operative relief of pain].

Marianna Borsodi et al.

Orvosi hetilap, 149(39), 1847-1852 (2008-09-23)

The authors compared the potency, safety and tolerability of combined infusion containing non-steroid anti-inflammation diclofenac and central muscle relaxant orphenadrine, and those of tramadol HCl, during postoperative pain relief after low and middle category operations. The test was an open

Orphenadrine induces secondarily generalized convulsive status epilepticus in rats.

Konrad Rejdak et al.

Brain research bulletin, 84(6), 389-393 (2011-01-29)

The current study was aimed to assess the convulsant potency of orphenadrine (ORPH) in rats together with a screen of different conventional antiepileptic drugs (AEDs) on their efficacy to suppress it. ORPH was administered intraperitoneally (i.p.) in doses of 50-80

Vibrational spectra and density functional theoretical calculations on the anti-neurodegenerative drug: Orphenadrine hydrochloride.

Bismi Edwin et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 838-846 (2012-08-21)

Vibrational spectral analysis and quantum chemical computations based on density functional theory have been performed on the anti-neuro-degenerative drug Orphenadrine hydrochloride. The geometry, intermolecular hydrogen bond, and harmonic vibrational frequencies of the title molecule have been investigated with the help

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奥芬那君 盐酸盐

European Pharmacopoeia (EP) Reference Standard

About This Item

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属性

等级

API类

制造商/商品名称

应用

包装形式

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

生化/生理作用

包装

其他说明

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安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

储存分类代码

WGK

闪点(°F)

闪点(°C)

文件

分析证书(COA)

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奥芬那君盐酸盐