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安全信息

Y0000596

地西泮

European Pharmacopoeia (EP) Reference Standard

别名:

7-氯-1-甲基-5-苯基-3H-1,4-苯二氮䓬-2(1H)-酮, Ro 5-2807

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About This Item

经验公式（希尔记法）:
C16H13ClN2O
CAS号:
439-14-5
分子量:
284.74
MDL编号:
MFCD00057323
UNSPSC代码:
41116107
PubChem化学物质编号:
329831041
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

diazepam

制造商/商品名称

EDQM

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

AAOVKJBEBIDNHE-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Diazepam for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

地西泮(Diazepam)是一种苯二氮䓬类抗焦虑药。可作为GABAA受体苯二氮䓬调节位点的原型配体。
抗焦虑药；GABAA受体苯二氮卓调节位点的配体。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险声明

H301 + H311,H410

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Matteo Cerri et al.
PloS one, 9(11), e112849-e112849 (2014-11-15)
Neurons within the lateral hypothalamus (LH) are thought to be able to evoke behavioural responses that are coordinated with an adequate level of autonomic activity. Recently, the acute pharmacological inhibition of LH has been shown to depress wakefulness and promote
Ryota Inokuchi et al.
Medicine, 94(7), e555-e555 (2015-02-24)
Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We
Jean-Baptiste Faure et al.
Epilepsia, 55(5), 644-653 (2014-03-14)
Temporal lobe epilepsy is a relatively frequent, invalidating, and often refractory neurologic disorder. It is associated with cognitive impairments that affect memory and executive functions. In the rat lithium-pilocarpine temporal lobe epilepsy model, memory impairment and anxiety disorder are classically
Caio Maximino et al.
PloS one, 9(7), e103943-e103943 (2014-08-01)
A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which
James M Chamberlain et al.
JAMA, 311(16), 1652-1660 (2014-04-24)
Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. To test the hypothesis that lorazepam
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