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主要文件

34750

Sigma-Aldrich

2,6-二--丁基-4-甲基苯酚

purum, ≥99.0% (GC)

别名:

2,6-二-丁基甲酚, BHT, DBPC, 丁基化羟基甲苯, 丁基羟基甲苯

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250 MG
¥349.71
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¥1,326.77
5 G
¥5,792.70

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250 MG
¥349.71
1 G
¥1,326.77
5 G
¥5,792.70

About This Item

线性分子式:
[(CH3)3C]2C6H2(CH3)OH
CAS号:
分子量:
220.35
Beilstein:
1911640
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

¥349.71


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蒸汽密度

7.6 (vs air)

质量水平

蒸汽压

<0.01 mmHg ( 20 °C)

等级

purum

方案

≥99.0% (GC)

自燃温度

878 °F

沸点

265 °C (lit.)

mp

68-72 °C
69-73 °C (lit.)

溶解性

methanol: 0.1 g/mL, clear, colorless
methanol: soluble 100 mg/mL, clear, colorless

SMILES字符串

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

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一般描述

2,6-二-丁基-4-甲基苯酚是一种 4-烷基酚。它是一种抗氧化剂,并表现出通过氧化代谢介导的亲电醌甲醚毒性。它作为 Michael 受体,它与单亲核体和蛋白质的反应已被报道。[1]2,6-二-丁基-4-甲基苯酚与铕 (II)-二苯甲酮二阴离子配合物的反应已有报道。[2]食品添加剂 2,6-二--叔 -丁基-4-甲酚可促进小鼠急性肺毒性和肿瘤生长。[3]

应用

2,6-二--丁基-4-甲酚可用于制备有机铝化合物甲基铝双(2,6-二--丁基-4-烷基酚氧化物)。[4]

象形图

Environment

警示用语:

Warning

危险声明

预防措施声明

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

260.6 °F - open cup

闪点(°C)

127 °C - open cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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    Methylaluminum bis (2, 6-di-tert-butyl-4-alkylphenoxide). A new reagent for obtaining unusual equatorial and anti-Cram selectivity in carbonyl alkylation.
    Maruoka K, et al.
    Journal of the American Chemical Society, 107(15), 4573-4576 (1985)
    M A Lewis et al.
    Chemical research in toxicology, 9(8), 1368-1374 (1996-12-01)
    4-Alkylphenols, such as the antioxidant 2, 6-di-tert-butyl-4-methylphenol (BHT), exhibit toxicities that appear to be mediated by their oxidative metabolism to electrophilic quinone methides. Reactions of these Michael acceptors with simple nucleophiles and proteins have been reported, but little information is
    Novel crystal structure of ytterbium (II)-benzophenone dianion complex and its reaction with 2, 6-di-tert-butyl-4-methylphenol.
    Hou Z, et al.
    Journal of the Chemical Society. Chemical Communications, 9, 722-724 (1999)
    Rene Kupfer et al.
    Chemical research in toxicology, 15(8), 1106-1112 (2002-08-20)
    Acute pulmonary toxicity and tumor promotion by the food additive 2,6-di-tert-butyl-4-methylphenol (BHT) in mice are well documented. These effects have been attributed to either of two quinone methides, 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone (BHT-QM) formed through direct oxidation of BHT by pulmonary cytochrome P450
    A M Vijesh et al.
    European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
    In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized

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