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Merck
CN

B1378

Sigma-Aldrich

2,6-二--丁基-4-甲基苯酚

≥99.0% (GC), powder

别名:

2,6-二-丁基甲酚, BHT, DBPC, 丁基化羟基甲苯, 丁基羟基甲苯

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About This Item

线性分子式:
[(CH3)3C]2C6H2(CH3)OH
CAS号:
分子量:
220.35
Beilstein:
1911640
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

蒸汽密度

7.6 (vs air)

质量水平

蒸汽压

<0.01 mmHg ( 20 °C)

方案

≥99.0% (GC)

表单

powder

自燃温度

878 °F

沸点

265 °C (lit.)

mp

69-73 °C (lit.)

溶解性

ethanol: 100 mg/mL
vegetable oils: soluble

SMILES字符串

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

基因信息

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应用

  • BHT及其过氧化物(BHTOOH)的热解特性:BHT具有优异的抗氧化性,在特定条件下分解为BHTOOH(S Dai, et al., 2024)。
  • 低应力聚合物网络的松弛机制:BHT被用于聚合物网络,评估其对牙科复合树脂的机械性能和耐久性的影响(SH Lewis, et al., 2024)。
  • 药品包装标签的相容性和安全性:研究发现标签中含有BHT,说明BHT因其稳定性广泛用于药品包装(C Fu, et al., 2023)。

生化/生理作用

二丁基羟基甲苯 (BHT) 是一种酚类抗氧化剂。它可以抑制脂类过氧化。它会导致小鼠肺部损伤以及促进肿瘤生长,这可能是由于 BHT 的代谢产物造成,即 6-叔丁基-2-[2′-(2′-羟基甲基)-丙基]-4-甲基苯酚。还报道了 BHT 的代谢产物会引起培养细胞中的 DNA 链断裂以及核小体间 DNA 断裂(细胞凋亡的典型特征)。向大鼠进行单次 BHT 腹腔注射(60mg/kg 体重)会引起肝、肾、心脏、脾、大脑和肺部的核 DNA 甲基转移酶活动的显著提高。用 BHT 孵育肺泡巨噬细胞可以显著降低 TNF-α 的含量,这可以解释该抗氧化剂缓解炎症的机理。用 BHT 预孵育经阿司匹林处理的血小板可以抑制由蛋白激酶 C 活化剂引起的分泌、聚集以及蛋白质磷酸化。BHT 还可抑制由黄曲霉素 B1 诱发的肝癌形成。

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说明
价格

象形图

Environment

警示用语:

Warning

危险声明

预防措施声明

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

260.6 °F - open cup

闪点(°C)

127 °C - open cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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