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安全信息

M-015

Supelco

安眠酮标准液 溶液

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C16H14N2O
CAS号:
72-44-6
分子量:
250.30
MDL编号:
MFCD00057320
UNSPSC代码:
41116107
PubChem化学物质编号:
329817730
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)

浓度

1 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

2-8°C

SMILES字符串

Cc1ccccc1N2C(C)=Nc3ccccc3C2=O

InChI

1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3

InChI key

JEYCTXHKTXCGPB-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

一般描述

甲喹酮是一种镇静催眠药和中枢神经系统抑制剂，其以商品名Quaalude进行销售，可用于治疗失眠症。甲喹酮也有滥用的历史，其以迪斯科饼干、Lemmons和714s等街头名称闻名。此认证的溶液标准品可作为校准物或对照品中的起始材料，通过LC/MS或GC/MS，用于从尿液药物测试到法医分析和临床毒理学方面的各种应用中。

应用


  • 药代动力学研究：在药代动力学研究中，采用了液相色谱/串联质谱法分析甲喹酮，这对于了解其代谢和排泄模式至关重要。此类研究对于制定镇静催眠药的安全性和治疗指南至关重要（Yun et al., 2007）。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

储存分类代码

3 - Flammable liquids

WGK

WGK 1

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Antimalarials: shortages and searches.
Stanley Scheindlin
Molecular interventions, 5(5), 268-272 (2005-10-27)
Phenytoin intoxication induced by Mandrax (methaqualone).
Rajesh Verma et al.
Epilepsy research, 98(2-3), 281-282 (2011-10-25)
J Klimes et al.
Die Pharmazie, 51(9), 651-653 (1996-09-01)
A HPLC method for quantification of kebuzone and its metabolites in whole blood was developed. The compounds and the internal standard were isolated from blood by solid-phase extraction on a C-18 cartridge. A blood sample was to be hemolyzed before
F Benoist et al.
European journal of biochemistry, 240(3), 713-720 (1996-09-15)
The role of microsomal triacylglycerol transfer protein (MTP) in the secretion of apolipoprotein B-100 (apoB-100) has been studied using an inhibitor of MTP: 4'-bromo-3'-methylmetaqualone. In vitro, this compound inhibits trioleoylglycerol transfer between lipid vesicles mediated by MTP with an IC50
Meihui Pan et al.
The Journal of biological chemistry, 277(6), 4413-4421 (2001-11-13)
Although microsomal triglyceride transfer protein (MTP) and newly synthesized triglyceride (TG) are critical for co-translational targeting of apolipoprotein B (apoB100) to lipoprotein assembly in hepatoma cell lines, their roles in the later stages of lipoprotein assembly remain unclear. Using N-acetyl-Leu-Leu-norleucinal
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