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安全信息

F-907

Supelco

氟硝西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C16H12FN3O3
CAS号:
1622-62-4
分子量:
313.28
EC 号:
200-659-6
MDL编号:
MFCD00057906
UNSPSC代码:
41116107
PubChem化学物质编号:
329799782
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

CN(C1=CC=C([N+]([O-])=O)C=C1C(C2=CC=CC=C2F)=NC3)C3=O

InChI

1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3

InChI key

PPTYJKAXVCCBDU-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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一般描述

一种认证的加标溶液®适合用于临床毒理学、法医分析或尿液药物检测的GC/MS或LC/MS应用。氟硝西泮是一种中效苯二氮卓类药物，以Rohypnol的商品名作为催眠、镇静、抗惊厥和骨骼肌松弛剂进行出售的。

应用


  • 生物样品中氟硝西泮的检测：本研究讨论了脂肪乳剂（Intralipid）作为基质添加剂用于评估高脂血症患者死后血液的用途，在该过程中可以检测和定量测定氟硝西泮。这对毒理学分析至关重要，为药理学和法医学作出贡献 （Elenstål et al., 2023）。

  • 饮料中氟硝西泮的电化学检测：一种使用丝网印刷传感器快速检测酒精饮料中氟硝西泮（通常称为约会强奸药物）的创新方法。这种方法对公共健康和安全非常关键，该研究提供了一种快速有效的饮料污染检测方法（Papadopoulos et al., 2020）。



法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

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Paul D'Aloise et al.
Science & justice : journal of the Forensic Science Society, 52(1), 2-8 (2012-02-14)
Desorption electrospray ionization-mass spectrometry (DESI-MS), a novel ambient ionization technique, was used in this study for determining flunitrazepam in various alcoholic beverages. Using this technique, no pretreatment of the samples was necessary and identification of the drug was accomplished in
Vanessa Pauly et al.
International clinical psychopharmacology, 26(5), 268-277 (2011-08-11)
Fourteen benzodiazepine (BZD) or BZD-like medications were analyzed with three data sources aiming to assess prescription drug abuse for the year 2008. After a descriptive analysis, a principal component analysis was carried out to explore correlations between seven indicators obtained
T Suzuki et al.
Endoscopy, 44(1), 38-42 (2011-12-07)
Studies have estimated that failure of cecal intubation occurs with conventional colonoscopy in up to 10 % of cases. Double-balloon endoscopy (DBE) systems, magnetic endoscope imaging (MEI), and transparent cap have been shown to improve success rates for colonoscopy. This study
M A Mattila et al.
Drugs, 20(5), 353-374 (1980-11-01)
Flunitrazepam is a benzodiazepine derivative whose hypnotic effect predominates over the sedative, anxiolytic, muscle-relaxing and anticonvulsant effects characteristic of benzodiazepines. Thus, it is used as a night-time hypnotic and in anaesthesiology: due to the pronounced hypnotic effect it is not
Cristina Wasowski et al.
Biochemical pharmacology, 83(2), 253-259 (2011-11-08)
A set of sulfamides designed, synthesized and evaluated against maximal electroshock seizure (MES) and pentilenetetrazol (PTZ) tests with promising results, were tested for their affinity for the benzodiazepine binding site of the GABA(A) receptor. The most active compounds, N,N'-dicyclohexylsulfamide (7)
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