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安全信息

D-907

Supelco

地西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C16H13ClN2O
CAS号:
439-14-5
分子量:
284.74
EC 号:
200-659-6
MDL编号:
MFCD00057323
UNSPSC代码:
41116107
PubChem化学物质编号:
329798890
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

格式

single component solution

储存温度

-10 to -25°C

SMILES字符串

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

AAOVKJBEBIDNHE-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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相关类别

一般描述

该认证加标溶液® 适用于通过 HPLC、GC/MS 或 LC-MS/MS 法测试地西泮，从而用于法医分析、临床毒理学、尿液药物测试和大麻效力或杂质分析测试等应用。

地西泮是一种抗焦虑的苯二氮卓类药物，通常用于治疗焦虑症、肌肉痉挛和急性癫痫发作等。

应用

该认证标准物质（CRM）还可作如下用途：
  • 基于富勒烯功能化碳纳米管和离子液体修饰电极（C60-CNTs/IL）以电化学方式测定血清、尿液和片剂中的地西泮
  • 使用铋修饰的预处理铅笔石墨电极（BiPPGE）以差分伏安法分析地西泮片剂和人尿样品
  • 通过直接电子电离-液相色谱-串联质谱（EI-LC-MS/MS）法同时定量测定酒精饮料样品中的安定和氟硝西泮
  • 使用分散纳米材料-超声辅助-微萃取（DNUM）从尿液和血浆样品中提取地西泮和氯二氮环氧化物，并通过高效液相色谱-紫外（HPLC-UV）检测定量
  • 通过固相萃取后跟 LC-MS/MS 法测定对人口服液中安定及其代谢物进行多残留分析

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-160

2-氯地西泮-D4 溶液, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

D-163

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

监管及禁止进口产品

分析证书(COA)

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Voltammetric determination of diazepam using a bismuth modified pencil graphite electrode
Dehghanzade M and Alipour E
Analytical Methods : Advancing Methods and Applications, 8, 1995-2004 (2016)
Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite
Rahimi-Nasrabadi M, et al.
Sensors and Actuators B, Chemical, 240, 125-131 (2017)
Berend Malchow et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(7), 1019-1033 (2014-10-14)
Hippocampus volumes have been shown to be decreased in patients with major depression, but volume measurements are inconsistent in patients with bipolar disorder. Both disorders are associated with deficits in hippocampus-mediated cognitive functions. However, the underlying pathophysiology is widely unknown.
A Amiri Pebdani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1008, 146-155 (2015-12-15)
Benzodiazepines (BDs) are used widely in clinical practice, due to their multiple pharmacological functions. In this study a dispersive nanomaterial-ultrasound assisted- microextraction (DNUM) method followed by high performance liquid chromatography (HPLC) was used for the preconcentration and determination of chlordiazepoxide
Haim Bassan et al.
Epilepsia, 54(6), 1092-1098 (2013-04-05)
Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life. Initial treatment, mostly prehospital, aims to prevent its evolution to febrile status epilepticus (FSE) and reduce adverse outcome. Paucity of information is
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