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安全信息

C-907

Supelco

氯硝西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C15H10ClN3O3
CAS号:
1622-61-3
分子量:
315.71
EC 号:
200-659-6
MDL编号:
MFCD00057746
UNSPSC代码:
41116107
PubChem化学物质编号:
329775195
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1

InChI

1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)

InChI key

DGBIGWXXNGSACT-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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相关类别

一般描述

以Klonopin和Rivotril作为商品名出售的氯硝西泮是一种有效的长效苯二氮卓类药物，具有抗焦虑、抗惊厥、肌肉松弛和催眠作用。氯硝西泮是用于治疗癫痫的处方药。这款认证的Snap-N-Spike®溶液适合通过GC/MS或LC/MS应用用于法医分析、临床毒理学、尿液药物测试或疼痛处方监控。

应用


  • 氯硝西泮研究用溶液：用于测定苯二氮卓类衍生物（包括氯硝西泮）离解常数的化学计量学方法研究表明，它起到了提高药物分析精度的关键作用。该方法增进了我们对氯硝西泮在各种条件下相互作用的理解，有助于其在科学研究和药物制剂中的应用 (Shayesteh et al., 2015）。

  • 用于科学研究的高纯度氯硝西泮液体：一项在混合溶剂中采用药物（包括氯硝西泮）溶解度预测模型的研究提供了关于其溶解度行为的重要见解。这些知识对于我们优化药物配方、提高药物制剂的生物利用度非常重要（Jouyban et al., 2011）。

  • 作为GABA受体激动剂氯硝西泮在实验室实验中的应用：对人血浆中多苯二氮卓类药物（multibenzodiazepine）测定的研究突出了氯硝西泮在临床和药物研究中的重要性，尤其是它影响GABA受体的作用，这对我们了解其药理学影响至关重要 (Borges et al., 2009）。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

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Shigeru Morishita
Human psychopharmacology, 24(3), 191-198 (2009-03-31)
Clonazepam, first used for seizure disorders, is now increasingly used to treat affective disorders. We summarize the use of clonazepam to improve the management of depression. Clonazepam is useful for treatment-resistant and/or protracted depression, as well as for acceleration of
Raffaele Ferri et al.
Sleep medicine, 14(1), 24-29 (2012-10-27)
To analyze the differences in sleep structure and nocturnal motor activity between drug-free REM sleep behavior disorder (RBD) patients and those under therapy with clonazepam, and to evaluate the long-term longitudinal changes under continued therapy with clonazepam. Fifty-seven consecutive iRBD
Stuart J McCarter et al.
Sleep medicine, 14(3), 237-242 (2013-01-29)
REM sleep behavior disorder (RBD) is usually characterized by potentially injurious dream enactment behaviors (DEB). RBD treatment aims to reduce DEBs and prevent injury, but outcomes require further elucidation. We surveyed RBD patients to describe longitudinal treatment outcomes with melatonin
G Chouinard
The Journal of clinical psychiatry, 48 Suppl, 29-37 (1987-10-01)
This is a report on the efficacy of clonazepam in the treatment of acute mania. The advantages of clonazepam over standard neuroleptics are its rapidity of action, its lack of toxicity, and, particularly important, the fact that it does not
Taeko Sasai et al.
Parkinsonism & related disorders, 19(2), 153-157 (2012-09-20)
The clinical effectiveness of pramipexole (PPX), a candidate treatment for idiopathic rapid eye movement sleep behavior disorder (iRBD), varies among individuals. This study investigates factors associated with PPX effectiveness for treating RBD symptoms. Ninety-eight consecutive patients with RBD who had
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