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C-907

氯硝西泮标准液溶液

Name: 氯硝西泮标准液 溶液
Brand: CERILLIAN

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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About This Item

经验公式（希尔记法）:

C₁₅H₁₀ClN₃O₃

CAS号:

1622-61-3

分子量:

315.71

EC 号:

200-659-6

MDL编号:

MFCD00057746

UNSPSC代码:

41116107

PubChem化学物质编号:

329775195

NACRES:

NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

Snap-N-Spike^®/Snap-N-Shoot^®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant^®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

格式

single component solution

储存温度

−20°C

SMILES字符串

[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1

InChI

1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)

InChI key

DGBIGWXXNGSACT-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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一般描述

以Klonopin和Rivotril作为商品名出售的氯硝西泮是一种有效的长效苯二氮卓类药物，具有抗焦虑、抗惊厥、肌肉松弛和催眠作用。氯硝西泮是用于治疗癫痫的处方药。这款认证的Snap-N-Spike^®溶液适合通过GC/MS或LC/MS应用用于法医分析、临床毒理学、尿液药物测试或疼痛处方监控。

应用

Clonazepam research solution: Research on chemometric methods for determining the dissociation constants of benzodiazepine derivatives, including clonazepam, showcases its critical role in improving the precision of pharmaceutical analyses. This method enhances the understanding of clonazepam′s interactions in various conditions, aiding in its application in scientific research and drug formulation (Shayesteh et al., 2015).

High-purity clonazepam liquid for scientific study: A study employing solubility prediction models for drugs, including clonazepam, in mixed solvents provides significant insights into its solubility behavior. This knowledge is crucial for optimizing drug formulations and enhancing bioavailability in pharmaceutical preparations (Jouyban et al., 2011).

Clonazepam as a GABA receptor agonist in lab experiments: An investigation into multibenzodiazepine determination in human plasma emphasizes the importance of clonazepam in clinical and pharmaceutical research, particularly its role in affecting GABA receptors, crucial for understanding its pharmacological impacts (Borges et al., 2009).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险声明

H225,H301 + H311 + H331,H370

预防措施声明

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.

John C Oakley et al.

The Journal of pharmacology and experimental therapeutics, 345(2), 215-224 (2013-02-21)

Seizures remain uncontrolled in 30% of patients with epilepsy, even with concurrent use of multiple drugs, and uncontrolled seizures result in increased morbidity and mortality. An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss

An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder.

Raffaele Ferri et al.

Sleep medicine, 14(1), 24-29 (2012-10-27)

To analyze the differences in sleep structure and nocturnal motor activity between drug-free REM sleep behavior disorder (RBD) patients and those under therapy with clonazepam, and to evaluate the long-term longitudinal changes under continued therapy with clonazepam. Fifty-seven consecutive iRBD

Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review.

Shigeru Morishita

Human psychopharmacology, 24(3), 191-198 (2009-03-31)

Clonazepam, first used for seizure disorders, is now increasingly used to treat affective disorders. We summarize the use of clonazepam to improve the management of depression. Clonazepam is useful for treatment-resistant and/or protracted depression, as well as for acceleration of

Treatment outcomes in REM sleep behavior disorder.

Stuart J McCarter et al.

Sleep medicine, 14(3), 237-242 (2013-01-29)

REM sleep behavior disorder (RBD) is usually characterized by potentially injurious dream enactment behaviors (DEB). RBD treatment aims to reduce DEBs and prevent injury, but outcomes require further elucidation. We surveyed RBD patients to describe longitudinal treatment outcomes with melatonin

Clonazepam in acute and maintenance treatment of bipolar affective disorder.

G Chouinard

The Journal of clinical psychiatry, 48 Suppl, 29-37 (1987-10-01)

This is a report on the efficacy of clonazepam in the treatment of acute mania. The advantages of clonazepam over standard neuroleptics are its rapidity of action, its lack of toxicity, and, particularly important, the fact that it does not

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氯硝西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

About This Item

属性

等级

质量水平

形式

特点

包装

制造商/商品名称

drug control

浓度

技术

应用

格式

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

法律信息

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安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

靶器官

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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氯硝西泮标准液溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®