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Merck
CN
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文件

安全信息

A-903

Supelco

阿普唑仑标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式（希尔记法）:
C17H13ClN4
CAS号:
28981-97-7
分子量:
308.76
EC 号:
200-659-6
MDL编号:
MFCD00078881
UNSPSC代码:
41116107
PubChem化学物质编号:
329771027
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing

格式

single component solution

储存温度

−20°C

SMILES字符串

Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12

InChI

1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

InChI key

VREFGVBLTWBCJP-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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相关类别

一般描述

阿普唑仑是一种苯二氮卓类药物，可用于治疗焦虑症和恐慌症，包括广泛性或社交焦虑症。此认证的参考标准品通过LC/MS或GC/MS，可用于从法医分析和临床毒理学到尿液药物测试方面的各种应用中。阿普唑仑以商品名Xanax出售®。

应用


  • Alprazolam Solid Lipid Nanoparticles for Sustained Release: This study explores the development of Compritol-based Alprazolam solid lipid nanoparticles, demonstrating a novel approach for sustained release formulations in benzodiazepine biochemistry. The technique is critical for improving the pharmacokinetics of anxiolytic compounds, ensuring controlled release and enhanced bioavailability (Rao et al., 2022).

  • Extraction of Alprazolam in Biological Samples: Application of dispersive solid-phase extraction using nanographene oxide grafted with α-pyridylamine for alprazolam, which is significant for forensic and clinical toxicology. This method enhances the precision of benzodiazepine detection in complex biological matrices, pivotal for neuropharmacological studies (Parsayi Arvand et al., 2023).

  • Raman Spectroscopy in Drug Abuse Analysis: Utilization of portable Raman spectroscopy for the detection of drugs of abuse, including Alprazolam. This research underscores the importance of Alprazolam research solutions in developing rapid and non-destructive testing methods, contributing to advancements in forensic science (Santos et al., 2022).

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Xanax is a registered trademark of Pharmacia & Upjohn Company

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H-143

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F-095

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F-096

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

法规信息

监管及禁止进口产品

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Gary G Kay et al.
Postgraduate medicine, 124(3), 7-15 (2012-06-14)
To evaluate the cognitive effects of fesoterodine 4 and 8 mg versus placebo in healthy older adults. This was an active- and placebo-controlled, double-blind, double-dummy crossover study conducted using healthy volunteers (aged 65-85 years) with baseline Mini-Mental State Examination score
Angela C Rintoul et al.
The Medical journal of Australia, 198(4), 206-209 (2013-03-05)
To examine the rate of detection of alprazolam among cases of heroin-related death (HRD) in Victoria, including the relationship between alprazolam supply and HRDs. Population-based study of community alprazolam supply in Victoria and HRDs reported to the Victorian coroner from
Katherine R Marks et al.
Psychopharmacology, 231(14), 2741-2750 (2014-01-28)
Opioid antagonists (e.g., naltrexone) and positive modulators of γ-aminobutyric-acidA (GABAA) receptors (e.g., alprazolam) modestly attenuate the abuse-related effects of stimulants like amphetamine. The use of higher doses to achieve greater efficacy is precluded by side effects. Combining naltrexone and alprazolam
J M Jonas et al.
The Journal of clinical psychiatry, 54 Suppl, 25-45 (1993-10-01)
A review of the worldwide published literature was conducted to assess the efficacy and safety of alprazolam for the treatment of anxiety disorders, panic disorder, and depression in comparison with those of other active drugs (including other benzodiazepines and antidepressant
Dean T Acheson et al.
Human psychopharmacology, 27(4), 419-427 (2012-07-12)
Heightened anticipation of future events has been characterized as a feature of certain anxiety disorders. In functional magnetic resonance imaging studies, anticipation of fearful/threatening images has been shown to robustly activate the insular cortex and amygdala in healthy subjects, in
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