所有图片(1)
About This Item
经验公式（希尔记法）:
C8H12N4
分子量:
164.21
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案
98%
折射率
n20/D 1.587 (lit.)
沸点
277 °C (lit.)
密度
1.158 g/mL at 25 °C (lit.)
SMILES字符串
C1CN(CCN1)c2ncccn2
InChI
1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
InChI key
MRBFGEHILMYPTF-UHFFFAOYSA-N
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一般描述
1-（2-嘧啶基）哌嗪是一种基于哌嗪的衍生物。它是丁螺环酮的代谢产物。
应用
1-（2-嘧啶基）哌嗪可用于以下研究：
- 作为多肽羧基的衍生试剂。
- 磷酸肽分光光度分析过程中的羧基衍生化。
- 用于合成 3-{{（4-（嘧啶-2-基）哌嗪-1-基）甲基 }-1 H -吡咯并 [2,3- b ] 吡啶的起始试剂。
- 3-苯基-6-（4-（嘧啶-2-基）哌嗪-1-基）哒嗪-4-醇的合成。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
>230.0 °F
闪点(°C)
> 110 °C
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
A Gobert et al.
Neuroscience, 93(4), 1251-1262 (1999-09-29)
The serotonin1A receptor partial agonist, buspirone, also displays antagonist properties at D2 receptors and is metabolized to the alpha2-adrenergic receptor antagonist, 1-(2-pyrimidinyl-piperazine). Herein, we examined mechanisms underlying the influence of buspirone alone, and in association with the serotonin reuptake inhibitor
B J Cao et al.
Neuropharmacology, 36(8), 1089-1097 (1997-08-01)
It has been suggested that in vivo formation of the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) may be a major drawback in the use of buspirone as an anti-anxiety agent. To test this hypothesis, the effects of buspirone, alone or with proadifen (an
Lijuan Zhang et al.
Proteomics, 9(16), 4093-4097 (2009-08-07)
A novel strategy based on carboxy group derivatization is presented for specific characterization of phosphopeptides. By tagging the carboxy group with 1-(2-pyrimidyl) piperazine (PP), the ion charge states of phosphopeptides can be largely enhanced, showing great advantages for sequencing phosphorylated
I Berlin et al.
British journal of clinical pharmacology, 39(3), 243-249 (1995-03-01)
1. Because the 5-HT1A agonist anxiolytic azapirones have a common alpha 2-adrenoceptor antagonist metabolite, 1-(2-pyrimidinyl)-piperazine (1PP), we measured central and peripheral alpha 2-adrenoceptor dependent responses before and after intravenous administration of 0.15 mg clonidine when healthy subjects were taking buspirone
K T Kivistö et al.
Therapeutic drug monitoring, 21(3), 317-321 (1999-06-12)
Two separate gas chromatographic methods for the determination of buspirone and its active metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma are described. Both procedures involve solid-phase extraction (the packing material of the cartridges used was C8 for buspirone and a mixed-mode
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