所有图片(1)
别名:
哌嗪-1-甲酸叔丁酯
经验公式（希尔记法）:
C9H18N2O2
CAS号:
分子量:
186.25
Beilstein:
879985
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
检测方案
97%
形式
solid
mp
43-47 °C (lit.)
SMILES字符串
CC(C)(C)OC(=O)N1CCNCC1
InChI
1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
InChI key
CWXPZXBSDSIRCS-UHFFFAOYSA-N
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一般描述
1-Boc-哌嗪是-Boc保护的哌嗪。1-Boc-哌嗪与芳基碘的CuBr/1，1′交叉偶联。研究报道了铋-2-萘酚（催化剂）和K3PO4（碱）。1-Boc-哌嗪与芳基卤化物发生布赫华-哈特威格偶联反应。碘催化无溶剂N-Boc保护可制备80%产率的1-Boc-哌嗪。
应用
1-Boc-哌嗪可用于：
- （m·-苯氧基）苯基取代哌嗪衍生物系列的制备
- 通过活性阳离子开环聚合合成α,β-聚（2-噁唑啉）脂聚合物期间的终止步骤。
- 单取代哌嗪的制备，例如吲唑脱氧核糖核酸回旋酶抑制剂的合成
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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