343536
1-Boc-哌嗪
97%
别名:
哌嗪-1-甲酸叔丁酯
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关于此项目
经验公式（希尔记法）:
C9H18N2O2
化学文摘社编号:
分子量:
186.25
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
879985
产品名称
1-Boc-哌嗪, 97%
InChI
1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
SMILES string
CC(C)(C)OC(=O)N1CCNCC1
InChI key
CWXPZXBSDSIRCS-UHFFFAOYSA-N
assay
97%
form
solid
mp
43-47 °C (lit.)
Quality Level
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Application
1-Boc-哌嗪可用于：
- （m·-苯氧基）苯基取代哌嗪衍生物系列的制备
- 通过活性阳离子开环聚合合成α,β-聚（2-噁唑啉）脂聚合物期间的终止步骤。
- 单取代哌嗪的制备，例如吲唑脱氧核糖核酸回旋酶抑制剂的合成
General description
1-Boc-哌嗪是-Boc保护的哌嗪。1-Boc-哌嗪与芳基碘的CuBr/1，1′交叉偶联。研究报道了铋-2-萘酚（催化剂）和K3PO4（碱）。1-Boc-哌嗪与芳基卤化物发生布赫华-哈特威格偶联反应。碘催化无溶剂N-Boc保护可制备80%产率的1-Boc-哌嗪。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Florencio Zaragoza et al.
Journal of medicinal chemistry, 47(11), 2833-2838 (2004-05-14)
With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent
Akihiko Tanitame et al.
Bioorganic & medicinal chemistry letters, 14(11), 2857-2862 (2004-05-06)
In this study, we report the design, synthesis and structure-activity relationships of novel indazole derivatives as DNA gyrase inhibitors with Gram-positive antibacterial activity. Our results show that selected compounds from this series exhibit potent antibacterial activity against Gram-positive bacteria including
Dengfeng Dou et al.
Bioorganic & medicinal chemistry letters, 22(1), 377-379 (2011-11-29)
There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize an array of structurally-diverse derivatives which were screened for anti-norovius
Ravi Varala et al.
The Journal of organic chemistry, 71(21), 8283-8286 (2006-10-10)
An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular iodine (10 mol %) under solvent-free conditions at ambient temperature is
α,ω-Functionalized Poly (2-Oxazoline) s Bearing Hydroxyl and Amino Functions.
Reif M and Jordan R.
Macromolecular Chemistry and Physics, 212(16), 1815-1824 (2011)
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