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Key Documents

616454

Sigma-Aldrich

A 83-01

≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem

Synonym(s):

TGF-β RI Kinase Inhibitor IV, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV

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50 G
¥6,984.41
100 G
¥12,349.49
6 X 100 G
¥50,600.71

¥6,984.41

Available to ship on2025年4月27日Details

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Select a Size

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50 G
¥6,984.41
100 G
¥12,349.49
6 X 100 G
¥50,600.71

About This Item

Empirical Formula (Hill Notation):
C25H19N5S
CAS Number:
909910-43-6
Molecular Weight:
421.52
MDL number:
MFCD08705403
UNSPSC Code:
12352200
NACRES:
NA.54

¥6,984.41

Available to ship on2025年4月27日Details

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Product Name

TGF-β RI Kinase Inhibitor IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

Quality Level

200

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

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Show Differences

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This Item
G50150G100120U8878
Sephadex® LH-20

LH20100

Sephadex® LH-20

Sephadex® G-50 Medium

G50150

Sephadex® G-50

Sephadex® G-100 Medium

G100120

Sephadex® G-100

Sigma-Aldrich

U8878

Ultrogel® AcA 34

matrix

Agarose

matrix

Agarose

matrix

Agarose

matrix

3% acrylamide, 4% agarose

separation technique

size exclusion (SEC)

separation technique

size exclusion (SEC)

separation technique

size exclusion (SEC)

separation technique

size exclusion (SEC)

matrix active group

polymer

matrix active group

polymer

matrix active group

polymer

matrix active group

polymer

form

slurry

form

slurry

form

slurry

form

aqueous ethanol suspension

technique(s)

LPLC: suitable

technique(s)

LPLC: suitable

technique(s)

LPLC: suitable

technique(s)

LPLC: suitable

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

2-8°C

General description

A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ALK-4/5/7
Product does not compete with ATP.
Reversible: no
Target IC50: 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tojo, M., et al. 2005. Cancer Sci.96, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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