616454
A 83-01
≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem
别名:
TGF-β RI 激酶抑制剂 IV
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关于此项目
经验公式（希尔记法）:
C25H19N5S
化学文摘社编号:
分子量:
421.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
产品名称
TGF-β RI 激酶抑制剂 IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC50 = 45, 12, and 7.5 nM, respectively).
SMILES string
S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1
InChI
1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
InChI key
HIJMSZGHKQPPJS-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 20 mg/mL
shipped in
ambient
Quality Level
storage temp.
2-8°C
Biochem/physiol Actions
可逆：否
细胞可渗透性：是
主要靶标
ALK-4/5/7
ALK-4/5/7
产物不与ATP竞争。
靶标IC50：抑制ALK-4/5/7介导的荧光素酶转录活性测定分别为45、12和7.5 nM
Disclaimer
毒性：有害（C）
General description
一种细胞渗透性三取代吡唑化合物，已显示在表达单个I型TGF-β受体的Mv1Lu R4-2转染子中选择性抑制ALK-4/5/7介导（荧光素酶转录活性测定中IC50分别为45、12和7.5 nM），但不抑制ALK-1/2/3/6介导的细胞信号。在浓度为1 µM的情况下，抑制HaCaT细胞中TGF-β-诱导的Smad2磷酸化和NMuMG细胞中的上皮间质转化。
Other Notes
Tojo, M., et al. 2005.Cancer Sci.96, 791.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
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