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主要文件

616461

Sigma-Aldrich

TGF-β RI激酶抑制剂VI，SB431542

TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively).

别名:

TGF-β RI激酶抑制剂VI，SB431542, 4-[4-（3,4-亚甲二氧基苯基）-5-（2-吡啶基）-1H-咪唑-2-基]苯甲酰胺，二水合物，4-[4-（1,3-苯并二唑-5-基）-5-（2-吡啶基）-1H-咪唑-2-基]苯甲酰胺，二水合物，SB-431542

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About This Item

CAS号:
301836-41-9
MDL编号:
MFCD27976360
UNSPSC代码:
51111800
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

300

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

ethanol: 10 mg/mL
DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[nH]1c(nc(c1c4cc5c(cc4)OCO5)c3ncccc3)c2ccc(cc2)C(=O)N

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Anti-Peripherin Antibody, clone 1D4, ZooMAb® Rabbit Monoclonal

clone

4L5, recombinant monoclonal

clone

1N12, recombinant monoclonal

clone

5L3, recombinant monoclonal

clone

1D4, recombinant monoclonal

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

species reactivity

rat, human, mouse

species reactivity

mouse, human

species reactivity

rat, human, mouse

species reactivity

mouse, rat, human

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

biological source

rabbit (recombinant)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

一般描述

一种细胞渗透性三芳基咪唑化合物，经证明可有效抑制NIH 3T3细胞中组成性活性ALK4、ALK5或ALK7的载体介导表达后的细胞Smad2磷酸化（10 µM抑制剂抑制>90%），而在表达活性ALK1、2、3或6的NIH 3T3培养物中，TGF-βⅠ型受体的其他成员对Smad1磷酸化几乎没有影响。当在无细胞激酶分析中直接测试时，SB431542被证明能有效抑制ALK4和ALK5的活性（IC50分别为140 nM和94 nM），而对包括ALK2和ALK6在内的24种其他激酶（IC50在10 µM ATP存在下为≥10 µM）没有效力或大大降低效力。据报道，当与PD0325901（目录号444966）和噻唑维文（目录号420220）一起使用时，4-TF诱导的成纤维细胞培养产生人类IPSC的效率提高了>200倍。

包装

用惰性气体包装

警告

毒性：标准处理（A）

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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