推荐产品
product name
TGF-β RI激酶抑制剂VI，SB431542, InSolution, ≥97%
质量水平
检测方案
≥97% (HPLC)
形式
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
ambient
储存温度
−20°C
InChI
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI key
FHYUGAJXYORMHI-UHFFFAOYSA-N
一般描述
一种细胞渗透性三芳基咪唑化合物，经证明可有效抑制NIH 3T3细胞中组成性活性ALK4、ALK5或ALK7的载体介导表达后的细胞Smad2磷酸化（10 µM抑制剂抑制>90%），而在表达活性ALK1、2、3或6的NIH 3T3培养物中，TGF-βⅠ型受体的其他成员对Smad1磷酸化几乎没有影响。 当在无细胞激酶分析中直接测试时，SB431542被证明能有效抑制ALK4和ALK5的活性（IC50分别为140 nM和94 nM），而对包括ALK2和ALK6在内的24种其他激酶（IC50在10 µM ATP存在下为≥10 µM）没有效力或大大降低效力。据报道，当与PD0325901（目录号444966）和噻唑维文（目录号420220）一起使用时，4-TF诱导的成纤维细胞培养产生人类IPSC的效率提高了>200倍。
包装
用惰性气体包装
警告
毒性：刺激性（B）
外形
100 mM (5 mg/119 µl) SB431542（目录号616461）在DMSO中的溶液。
重悬
初次融化后，等分并冷冻（-20°C）。
其他说明
Ikushima, H., et al. 2009.Cell Stem Cell5, 504.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
188.6 °F
闪点(°C)
87 °C
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