跳转至内容

CN

Recurrent inactivating RASA2 mutations in melanoma.

Recurrent inactivating RASA2 mutations in melanoma.

Nature genetics (2015-10-27)

Rand Arafeh, Nouar Qutob, Rafi Emmanuel, Alona Keren-Paz, Jason Madore, Abdel Elkahloun, James S Wilmott, Jared J Gartner, Antonella Di Pizio, Sabina Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, Ken Dutton-Regester, Peter Johansson, Antonia L Pritchard, Nicola Waddell, Victoria K Hill, Jimmy C Lin, Yael Hevroni, Steven A Rosenberg, Javed Khan, Shifra Ben-Dor, Masha Y Niv, Igor Ulitsky, Graham J Mann, Richard A Scolyer, Nicholas K Hayward, Yardena Samuels

摘要

Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

材料

货号

品牌

产品描述

Sigma-Aldrich

盐酸, ACS reagent, 37%

Sigma-Aldrich

十二烷基硫酸钠, BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC)

Sigma-Aldrich

氯化钠, for molecular biology, DNase, RNase, and protease, none detected, ≥99% (titration)

Sigma-Aldrich

十二烷基硫酸钠, ≥99.0% (GC), dust-free pellets

Sigma-Aldrich

盐酸溶液, 1.0 N, BioReagent, suitable for cell culture

Sigma-Aldrich

氯化钠溶液, 5 M in H₂O, BioReagent, for molecular biology, suitable for cell culture

Sigma-Aldrich

氯化钠溶液, 0.9% in water, BioXtra, suitable for cell culture

Sigma-Aldrich

氯化钠, BioXtra, ≥99.5% (AT)

Sigma-Aldrich

十二烷基硫酸钠溶液, BioUltra, for molecular biology, 10% in H₂O

Sigma-Aldrich

氟化钠, ACS reagent, ≥99%

Sigma-Aldrich

盐酸, 36.5-38.0%, BioReagent, for molecular biology

Sigma-Aldrich

氯化钠, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%

Sigma-Aldrich

十二烷基硫酸钠, ACS reagent, ≥99.0%

Sigma-Aldrich

盐酸, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., fuming, ≥37%, APHA: ≤10

Sigma-Aldrich

十二烷基硫酸钠, ReagentPlus^®, ≥98.5% (GC)

SAFC

氯化钠溶液, 5 M

Sigma-Aldrich

盐酸, meets analytical specification of Ph. Eur., BP, NF, fuming, 36.5-38%

Sigma-Aldrich

十二烷基硫酸钠, BioUltra, for molecular biology, ≥99.0% (GC)

Sigma-Aldrich

十二烷基硫酸钠溶液, BioUltra, for molecular biology, 20% in H₂O

Supelco

盐酸溶液, volumetric, 0.1 M HCl (0.1N), endotoxin free

Sigma-Aldrich

正钒酸钠, ≥90% (titration)

Sigma-Aldrich

氯化钠溶液, BioUltra, for molecular biology, ~5 M in H₂O

Sigma-Aldrich

氯化钠, BioUltra, for molecular biology, ≥99.5% (AT)

Sigma-Aldrich

氯化钠, meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5%

Sigma-Aldrich

氯化钠, 99.999% trace metals basis

Sigma-Aldrich

氯化钠溶液, 5 M

Sigma-Aldrich

正钒酸钠, 99.98% trace metals basis

Supelco

十二烷基硫酸钠, dust-free pellets, suitable for electrophoresis, for molecular biology, ≥99.0% (GC)

Sigma-Aldrich

盐酸溶液, ~6 M in H₂O, for amino acid analysis

Sigma-Aldrich

氟化钠, 99.99% trace metals basis