跳转至内容
Merck
CN
所有图片(4)

文件

S6508

Sigma-Aldrich

正钒酸钠

≥90% (titration)

别名:

Trisodium vanadate

登录查看公司和协议定价
所有图片(4)

About This Item

线性分子式:
Na3VO4
CAS号:
13721-39-6
分子量:
183.91
EC 号:
237-287-9
MDL编号:
MFCD00003511
UNSPSC代码:
12352200
PubChem化学物质编号:
24899708
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

检测方案

≥90% (titration)

形式

crystalline powder

反应适用性

reagent type: catalyst
core: vanadium

颜色

white to off-white

mp

850-866 °C (lit.)

溶解性

H2O: soluble

SMILES字符串

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

应用

正钒酸钠被用于制备胰岛素受体激酶脱磷酸化检测的终止液。26 它是用于开发利用表面固定抗体的Matrix ChIP的试剂之一。27

生化/生理作用

正钒酸钠可抑制辐射触发的p53介导的细胞凋亡激活。它减少了小鼠全身辐照引起的造血综合征、造血功能和延迟遗传毒性效应的不利影响。24 正钒酸盐与甲萘醌联合使用，可以防止脱落人胶质瘤细胞在抗癌药作用下发生迁移。25
抑制 ATP 酶、碱性磷酸酶和酪氨酸磷酸酶。在酸性 PH 值下形成的十钒酸盐可抑制肌醇基 1,4,5-三磷酸 (IP3)-诱导 Ca2+ 从内分泌细胞中的释放以及阻止 IP3 与其受体在脑组织中的结合。

特点和优势

《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究的特色产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

其他说明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

  1. How do I prepare solutions of Product S6508, Sodium Orthovanadate?

    Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.

  2. How do I store solutions of Product S6508, Sodium Orthovanadate?

    Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.

  3. What is the amount of S6508, Sodium orthovanadate, needed for inhibition?

    For ATPase, a 0.5-1 μM concentration of sodium orthovanadate inhibited 50% of the activity. Please see the product information sheet (under Documents, above) which provides references on several other enzymes.

  4. Which enzymes does S6508 inhibit?

    Sodium orthovanadate is an inhibitor of ATPase, alkaline phosphatase and tyrosine phosphatase.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

C Cerella et al.
Cell death & disease, 6, e1782-e1782 (2015-06-13)
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is
Christopher N J Young et al.
Autophagy, 11(1), 113-130 (2015-02-24)
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involved are not
Serena Orlando et al.
Nucleic acids research, 43(14), 6860-6873 (2015-06-15)
Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
Erika López-Arribillaga et al.
Development (Cambridge, England), 142(1), 41-50 (2014-12-07)
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic
查看所有相关文献

商品

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门