567540
原钒酸钠
A broad spectrum potent inhibitor of protein tyrosine phosphatases.
别名:
原钒酸钠, PTP抑制剂X
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关于此项目
经验公式（希尔记法）:
Na3O4V
化学文摘社编号:
分子量:
183.91
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
产品名称
原钒酸钠, A broad spectrum potent inhibitor of protein tyrosine phosphatases.
SMILES string
[V](=O)([O-])([O-])[O-].[Na+].[Na+].[Na+]
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
InChI key
IHIXIJGXTJIKRB-UHFFFAOYSA-N
description
RTECS - YW1120000
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
可逆：否
细胞可渗透性：否
主要靶标
Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶
Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶
产物不与ATP竞争。
Disclaimer
毒性：有害（C）
General description
一种广谱有效的蛋白质酪氨酸磷酸酶抑制剂。也可抑制Na+、K+ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶。最近研究表明，在微摩尔范围内，可抑制鼠伤寒沙门氏菌麦芽糖（MalFGK2）重组结合蛋白依赖性ATP结合盒（ABC）转运体的ATP酶活性。可通过过氧化氢转化为过钒酸盐。
Other Notes
Huyer, G., et al. 1997.J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995.Biochem.Biophys.Res. Commun.216, 589.
Levchuck, S.G., et al. 1994.Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989.Biochem.J.262, 83.
Swarup, G., et al. 1982.Biochem.Biophys.Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A.1979.Biochem.J.181, 247.
Hunke, S., et al. 1995.Biochem.Biophys.Res. Commun.216, 589.
Levchuck, S.G., et al. 1994.Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989.Biochem.J.262, 83.
Swarup, G., et al. 1982.Biochem.Biophys.Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A.1979.Biochem.J.181, 247.
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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商品
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
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