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Merck
CN
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安全信息

TRUERGD

Sigma-Aldrich

TrueGel3D RGD

Integrin Adhesion Peptide

别名:

3D cell culture matrix

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About This Item

UNSPSC代码:
12352207
NACRES:
NA.71

运输

dry ice

储存温度

−20°C

一般描述

TrueGel3D®是各种不同种类的商业化聚合物支架，用于体外肿瘤模型的三维培养。水凝胶中的RGD肽用于细胞粘附。
细胞外基质蛋白（纤连蛋白，玻连蛋白）上的 RGD 序列促进细胞与细胞整联蛋白受体的粘附。TrueGel3D® RGD 肽 N 端的巯基可作为将 RGD 基序与聚合物（Dextran/PVA）结合的连接子。聚合物上缀合的 RGD 基序可促进细胞与适当整联蛋白受体的粘附。

应用

具有细胞粘附基序（RGD）的聚合物用于产生细胞粘附水凝胶

特点和优势

包含细胞粘附基序 RGD（乙酰基-Cys-Doa * -Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2），可与细胞上适当的整联蛋白受体结合。

*Doa：8-氨基-3,6-二氧杂辛酸

组分

TRUERGD 包含 RGD 可降解聚合物（冻干的和水）

法律信息

TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

法规信息

常规特殊物品

分析证书(COA)

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L P Ferreira et al.
Acta biomaterialia, 75, 11-34 (2018-05-29)
Three-dimensional multicellular tumor models are receiving an ever-growing focus as preclinical drug-screening platforms due to their potential to recapitulate major physiological features of human tumors in vitro. In line with this momentum, the technologies for assembly of 3D microtumors are
Steven R Caliari et al.
Nature methods, 13(5), 405-414 (2016-04-29)
There is growing appreciation of the role that the extracellular environment plays in regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in concert, can drastically alter cell function. Biomaterials, and particularly hydrogels, have been developed and implemented

商品

Co-culture of Tumor and Stromal Cells in TrueGel3D™ Hydrogels

TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.

Utilization of TrueGel3D™ Hydrogels to Study Fibroblast Spreading

Fibroblasts that are present in the stroma secrete glycoproteins and polysaccharides to form extracellular matrix. They maintain the structural integrity within the connective tissue and play a key role in cancer, chronic obstructive pulmonary diseases, idiopathic pulmonary fibrosis, scleroderma and several other diseases.

True Gel3D™ Hydrogel Troubleshooting

Troubleshoot TrueGel3D™ hydrogel formation and cell viability issues with RGD-degradable polymer and CD cell-degradable crosslinker.

TrueGel3D™ Hydrogel for 3D Cell Culture

TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions

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实验方案

TrueGel3D™ Hydrogel Prep Protocol

TrueGel3D™ hydrogel enables cell encapsulation for 3D culture, mimicking native tissue environment with chemically defined properties.

TrueGel3D™ Hydrogel Prep Protocol

TrueGel3D™ is a chemically defined hydrogel for 3D cell growth, facilitating microchannel filling with slow gelation.

Advanced Protocol: How to Customize your TrueGel3D™ Hydrogel

An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation

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