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Merck
CN

TRUERGD

TrueGel3D RGD

Integrin Adhesion Peptide

别名:

3D细胞培养基质

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关于此项目

NACRES:
NA.71
UNSPSC Code:
12352207
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产品名称

TrueGel3D RGD, Integrin Adhesion Peptide

shipped in

dry ice

storage temp.

−20°C

Application

具有细胞粘附基序(RGD)的聚合物用于产生细胞粘附水凝胶

Features and Benefits

包含细胞粘附基序 RGD(乙酰基-Cys-Doa * -Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2),可与细胞上适当的整联蛋白受体结合。

*Doa:8-氨基-3,6-二氧杂辛酸

General description

TrueGel3D®是各种不同种类的商业化聚合物支架,用于体外肿瘤模型的三维培养。水凝胶中的RGD肽用于细胞粘附。
细胞外基质蛋白(纤连蛋白,玻连蛋白)上的 RGD 序列促进细胞与细胞整联蛋白受体的粘附。TrueGel3D® RGD 肽 N 端的巯基可作为将 RGD 基序与聚合物(Dextran/PVA)结合的连接子。聚合物上缀合的 RGD 基序可促进细胞与适当整联蛋白受体的粘附。

Other Notes

TRUERGD 包含 RGD 可降解聚合物(冻干的和水)

Legal Information

TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

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Steven R Caliari et al.
Nature methods, 13(5), 405-414 (2016-04-29)
There is growing appreciation of the role that the extracellular environment plays in regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in concert, can drastically alter cell function. Biomaterials, and particularly hydrogels, have been developed and implemented
L P Ferreira et al.
Acta biomaterialia, 75, 11-34 (2018-05-29)
Three-dimensional multicellular tumor models are receiving an ever-growing focus as preclinical drug-screening platforms due to their potential to recapitulate major physiological features of human tumors in vitro. In line with this momentum, the technologies for assembly of 3D microtumors are

商品

TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.

TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions

Fibroblasts that are present in the stroma secrete glycoproteins and polysaccharides to form extracellular matrix. They maintain the structural integrity within the connective tissue and play a key role in cancer, chronic obstructive pulmonary diseases, idiopathic pulmonary fibrosis, scleroderma and several other diseases.

Troubleshoot TrueGel3D™ hydrogel formation and cell viability issues with RGD-degradable polymer and CD cell-degradable crosslinker.

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实验方案

An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation

TrueGel3D hydrogel enables cell encapsulation for 3D culture, mimicking native tissue environment with chemically defined properties.

TrueGel3D™ is a chemically defined hydrogel for 3D cell growth, facilitating microchannel filling with slow gelation.

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