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T9262

他莫昔芬柠檬酸盐

Name: 他莫昔芬 柠檬酸盐
Brand: SIGMA

≥99% (TLC), powder, PKC inhibitor

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别名:

(Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯

经验公式（希尔记法）:

C₂₆H₂₉NO · C₆H₈O₇

CAS号:

54965-24-1

分子量:

563.64

EC 号:

259-415-2

MDL编号:

MFCD00058321

UNSPSC代码:

12161501

PubChem化学物质编号:

24278059

NACRES:

NA.77

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Sigma-Aldrich

T5648

泰莫西芬

Sigma-Aldrich

T2859

泰莫西芬

USP

1643306

柠檬酸他莫昔芬

Sigma-Aldrich

H7904

(Z)-4-羟三苯氧胺

Sigma-Aldrich

C8267

玉米油

Sigma-Aldrich

579000

Tamoxifen Citrate

Supelco

T-143

他莫昔芬溶液

Sigma-Aldrich

H6278

4-羟基他莫西芬

Supelco

85256

泰莫西芬

T0014000

他莫昔芬柠檬酸盐

质量水平

200

检测方案

≥99%

溶解性

methanol: soluble 50 mg/mL, clear, colorless

创始人

AstraZeneca

储存温度

2-8°C

SMILES字符串

OC(=O)CC(O)(CC(O)=O)C(O)=O.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

基因信息

human ... ESR1(2099) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

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应用

他莫昔芬已被用于分析其对人乳腺癌细胞辐射敏感性和类固醇受体含量的影响。也用于研究雌性大鼠肝组织中三酰甘油的蓄积。此外，有研究报道环境磁场可阻断他莫昔芬在人乳腺癌细胞中的抗增殖功能。

生化/生理作用

蛋白激酶 C 抑制剂。诱发人类恶性神经胶质瘤细胞系的细胞凋亡。他莫昔芬及其代谢产物 4-羟基他莫昔芬是选择性雌激素反应调节剂 (SERM)，在乳腺中用作雌激素拮抗剂。阻止乳腺肿瘤细胞中雌二醇刺激的 VEGF 的产生。

特点和优势

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

该化合物由 AstraZeneca 公司开发。若要浏览其他制药公司研发的化合物和批准的药物/候选药物列表，请单击此处。

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

制备说明

枸橼酸他莫昔芬盐溶于 50 mg/mL 甲醇，形成澄清、无色溶液。

象形图

GHS08,GHS07,GHS09

警示用语：

Danger

危险声明

H302,H350,H360D,H410

预防措施声明

P201 - P273 - P301 + P312 + P330 - P308 + P313

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

分析证书(COA)

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Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line.

J D Harland et al.

Bioelectromagnetics, 18(8), 555-562 (1997-01-01)

We have previously reported that environmental-level magnetic fields (1.2 microT [12 milligauss], 60 Hz) block the growth inhibition of the hormone melatonin (10(-9) M) on MCF-7 human breast cancer cells in vitro. We now report that the same 1.2 microT

Changes in radiation sensitivity and steroid receptor content induced by hormonal agents and ionizing radiation in breast cancer cells in vitro.

G H Paulsen et al.

Acta oncologica (Stockholm, Sweden), 35(8), 1011-1019 (1996-01-01)

Possible influences of tamoxifen and estradiol on in vitro radiation sensitivity and cellular receptor content after irradiation and/or tamoxifen treatment were studied in breast cancer cell lines; estrogen receptor (ER) and progesterone receptor (PgR) positive cell lines MCF-7 and MCF-7/TAM(R)-1

Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver.

Oddrun Anita Gudbrandsen et al.

Journal of lipid research, 47(10), 2223-2232 (2006-07-26)

Tamoxifen can induce hepatic steatosis in women. In this study, we wanted to elucidate the mechanism behind the tamoxifen-induced accumulation of triacylglycerol in liver in female rats, and we hoped to prevent this development by combination treatment with the modified

Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343.

Kevin S Hughes et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), 2382-2387 (2013-05-22)

To determine whether there is a benefit to adjuvant radiation therapy after breast-conserving surgery and tamoxifen in women age ≥ 70 years with early-stage breast cancer. Between July 1994 and February 1999, 636 women (age ≥ 70 years) who had

Markers of systemic inflammation predict survival in patients with advanced renal cell cancer.

P Fox et al.

British journal of cancer, 109(1), 147-153 (2013-06-20)

The host inflammatory response has a vital role in carcinogenesis and tumour progression. We examined the prognostic value of inflammatory markers (albumin, white-cell count and its components, and platelets) in pre-treated patients with advanced renal cell carcinoma (RCC). Using data

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他莫昔芬柠檬酸盐

≥99% (TLC), powder, PKC inhibitor

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属性

质量水平

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溶解性

创始人