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Merck
CN

PRKCG

protein kinase C, gamma

Synonyms:
PKC-gamma, PKCC, PKCG, SCA14
Species:
Human PRKCG (5582), Mouse Prkcg (18752), Rat Prkcg (24681), cow PRKCG (282002), Horse PRKCG (100062549), sheep PRKCG (101116423), naked mole-rat Prkcg (101698346), Domestic Rabbit PRKCG (100009102), domestic cat PRKCG (101082196), dog PRKCG (484316) ...More
UniProtKB ID:
P05129
Gene ID:
  • Human(5582) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
  • Mouse(18752) protein kinase C, gamma
  • Rat(24681) protein kinase C, gamma
  • cow(282002) protein kinase C, gamma
  • Horse(100062549) protein kinase C, gamma
  • sheep(101116423) protein kinase C, gamma
  • naked mole-rat(101698346) protein kinase C, gamma
  • Domestic Rabbit(100009102) protein kinase C, gamma
  • domestic cat(101082196) protein kinase C, gamma
  • dog(484316) protein kinase C, gamma
  • domestic guinea pig(100733947) protein kinase C, gamma
  • Zebrafish(100003514) protein kinase C, gamma

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Small Molecule - Agonist

Product Number
Description
Species
O1008
Oleic acid, ≥99% (GC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1300371
Anti-PKCγ (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
ZRB2310
Anti-PKCγ Antibody, clone 2B9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, rat
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
ZRB2362
Anti-p-PKCγ (Thr514) Antibody, clone 4F20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
inhibition assay
western blot
SAB5702703
Anti-PKC gamma Antibody, clone 5F2X3, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
western blot
HPA054560
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
I7016
H-7 dihydrochloride, ≥98% (HPLC),
Species
human
O1008
Oleic acid, ≥99% (GC),
Species
human
SML0428
GSK690693, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
K4518
PKCγ, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
EHU034121
MISSION® esiRNA, targeting human PRKCG,
Species
human