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T7508

Sigma-Aldrich

丁卡因 盐酸盐

≥99%

别名:

4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐

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About This Item

经验公式（希尔记法）:
C15H24N2O2 · HCl
CAS号:
136-47-0
分子量:
300.82
MDL编号:
MFCD00038912
UNSPSC代码:
12352200
PubChem化学物质编号:
57654697
NACRES:
NA.77

质量水平

200

方案

≥99%

溶解性

chloroform: soluble 30 parts
alcohol: soluble 40 parts
H2O: soluble mg/mL
acetone: insoluble
benzene: insoluble
diethyl ether: insoluble

SMILES字符串

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

InChI key

PPWHTZKZQNXVAE-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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应用

盐酸丁卡因已用于研究脊髓麻醉的药理作用。盐酸丁卡因也被用作蛋白酶消化缓冲液的组分。
眼用局部麻醉药；用于脊髓麻醉

生化/生理作用

阻断 Ca2+ 从肌浆网的电压敏感性释放。

特点和优势

该化合物在受体分类和信号转导手册的环核苷酸门控（CNG）和超极化激活的环核苷酸门控（HCN）通道页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

制备说明

盐酸丁卡因溶于水，浓度为50 mg/mL，得到无色澄清溶液。它也可溶于40份酒精和30份氯仿。但是，它实际上不溶于醚、苯或丙酮。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H319,H336

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
WXBF4335V
WXBF2279V
WXBD8324V
SLCK0239
SLBP8406V

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L Langerman et al.
Anesthesiology, 74(1), 105-107 (1991-01-01)
A novel approach for increasing the duration of anesthesia after a single subarachnoid injection of a local anesthetic is presented. Tetracaine 1% 0.5 mg/kg was administered in 10% glucose or in lipid solution (iophendylate) in two groups of rabbits via
A M Knight et al.
European journal of immunology, 22(3), 879-882 (1992-03-01)
Recent reports have shown that both exogenous and endogenous mouse mammary tumor viruses (MMTV) can encode superantigens. Transfection and transgenic studies have identified the open reading frame (ORF) present in the 3' long terminal repeat (LTR) as encoding superantigen function.
Gabriel C Gaviola et al.
The Laryngoscope, 123(4), 852-858 (2013-02-14)
Transnasal endoscopy is commonly performed in an outpatient otolaryngology setting. Patients are typically administered a topical anesthetic and decongestant prior to this procedure to alleviate discomfort and improve visualization. There is no consensus on which topical anesthetic is most effective
Patrick E McCleskey et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(1 Pt 1), 82-91 (2013-01-03)
Few published studies have analyzed serum lidocaine levels and individual patient characteristics affecting metabolism after application of compounded topical anesthetics. To measure serum lidocaine levels during and cutaneous side effects after standardized application of 23% lidocaine/7% tetracaine compounded anesthetic to
K Ruetzler et al.
British journal of anaesthesia, 109(5), 790-796 (2012-07-27)
Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anaesthetic. An alternative is topical anaesthesia, such as Rapydan which is a novel topical anaesthetic patch containing 70 mg
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