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Merck
CN
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安全信息

SML3700

Sigma-Aldrich

TPC2-A1-P

≥98% (HPLC)

别名:

5-(5-Bromo-2-(trifluoromethoxy)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid, TPC2 agonist H07

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1 MG
CN¥188.61
5 MG
CN¥932.18
10 MG
CN¥1,447.79
50 MG
CN¥6,302.72

CN¥188.61

国内现货，预计发货时间April 07, 2025详情

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1 MG
CN¥188.61
5 MG
CN¥932.18
10 MG
CN¥1,447.79
50 MG
CN¥6,302.72

About This Item

经验公式（希尔记法）:
C20H21BrF3NO3
CAS号:
2804595-86-4
分子量:
460.28
MDL编号:
MFCD32878271
UNSPSC代码:
12352200
NACRES:
NA.21

CN¥188.61

国内现货，预计发货时间April 07, 2025详情

获取大包装报价

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (Warmed)

储存温度

2-8°C

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此商品
MBD0015MBD0020D8417
DAPI for nucleic acid staining

D9542

DAPI

DAPI ready made solution For Nuclear counterstain in immunoflourecence microscopy, High Content Screening (HCS), Chromosome staining and flow cytometry (FACS)., 1 mg/mL

MBD0015

DAPI ready made solution

DAPI ready made solution with Antifade For Nuclear counterstain in Fluorescence Microscopy

MBD0020

DAPI ready made solution with Antifade

4′,6-Diamidino-2-phenylindole dihydrochloride powder, BioReagent, suitable for cell culture, ≥98% (HPLC and TLC), suitable for fluorescence

D8417

4′,6-Diamidino-2-phenylindole dihydrochloride

technique(s)

transfection: suitable

technique(s)

transfection: suitable

technique(s)

DNA extraction: suitable, DNA sequencing: suitable, PCR: suitable

technique(s)

cell culture | mammalian: suitable

grade

for molecular biology

grade

-

grade

-

grade

-

fluorescence

λex 340 nm; λem 488 nm (nur DAPI), λex 364 nm; λem 454 nm (DAPI-DNA-Komplex)

fluorescence

λex 340 nm; λem 488 nm (nur DAPI), λex 364 nm; λem 454 nm (DAPI-DNA-Komplex)

fluorescence

λex 340 nm; λem 488 nm (nur DAPI), λex 364 nm; λem 454 nm (DAPI-DNA-Komplex)

fluorescence

λex 340 nm; λem 488 nm (nur DAPI), λex 364 nm; λem 454 nm (DAPI-DNA-Komplex)

solubility

H2O: 20 mg/mL, PBS: insoluble

solubility

water: soluble

solubility

-

solubility

H2O: 20 mg/mL, PBS: insoluble

form

powder

form

liquid

form

liquid

form

powder

生化/生理作用

Selective two pore segment channel 2 (TCP2) agonist that preferentially mimics the Na+ signals-inducing action of PI(3,5)P2.
TPC2-A1-P is a selective two pore segment channel 2 (TCP2) agonist that mimics the action of PI(3,5)P2 where it preferentially induces Na+ signals (EC50 = 0.6 µM). In contrast, TPC2-A1-N is a much weaker Ca2+ current inducer when compared to NAADP and TPC2-A1-N. TPC2-A1-P, but not the Ca2+ signals agonist TPC2-A1-N, activates TPC2-dependent lysosomal exocytosis (30 µM, murine macrophages), while TPC2-A1-N, but not TPC2-A1-P, causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 µM, TPC2-expressing HeLa cells).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    分析证书(COA)

    Lot/Batch Number
    0000254960
    0000254961
    0000245878
    0000245878
    0000254961

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    Ponsawan Netcharoensirisuk et al.
    Scientific reports, 11(1), 8515-8515 (2021-04-21)
    Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function polymorphisms in hTPC2 are associated with decreased melanin production and blond hair color. Vice versa genetic ablation of TPC2 increases
    Marco Keller et al.
    Beilstein journal of organic chemistry, 17, 2716-2725 (2021-11-23)
    We present a systematic investigation on an improved variant of the N-acyl-Pictet-Spengler condensation for the synthesis of 1-benzyltetrahydroisoquinolines, based on our recently published synthesis of N-methylcoclaurine, exemplified by the total syntheses of 10 alkaloids in racemic form. Major advantages are
    Philipp Rühl et al.
    Scientific reports, 11(1), 8313-8313 (2021-04-17)
    The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal storage disease, while temporary inhibition of this ion channel has been proposed to be beneficial in cancer therapy.
    Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
    Cell Chemical Biology, 28(8) (2021)
    Wei Xiong Siow et al.
    Journal of cell science, 135(6) (2022-03-12)
    Liver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has gained focus in cancer research because
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