所有图片(1)
别名:
2-（2-氯乙酰基）-1-甲基-2,3,4,9-四氢-1H-吡啶 [3,4-b] 吲哚-1-羧酸甲酯, 2-（2-氯乙酰基）-2,3,4,9-四氢-1-甲基-1H-吡啶 [3,4-b] 吲哚-1-甲酸甲酯
经验公式（希尔记法）:
C16H17ClN2O3
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: 12 mg/mL, clear
储存温度
2-8°C
SMILES字符串
COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
InChI
1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
InChI key
BCSIRYFYAKLJDK-UHFFFAOYSA-N
应用
PDI 抑制剂 16F16 可用于蛋白质二硫键异构酶介导的细胞信号传导研究。
PDI抑制剂16F16已被用于抑制PDI（蛋白质二硫键异构酶）的功能，以检测人胚肾细胞中PDI的功能保守性（functional conservation）。
生化/生理作用
16F16 是一种蛋白质二硫键异构酶 (PDI) 抑制剂，首次在屏幕亨廷顿蛋白诱导细胞凋亡的化合物筛选中发现。16F16 不仅能抑制错误折叠的蛋白突变体亨廷顿基因诱导的细胞凋亡，还能保护大鼠神经元免受 Aβ 肽引发的细胞死亡。这种抑制剂的作用有助于确定一个新的机制，在这个机制中，细胞死亡途径通过 PDI 上调被蛋白质错误折叠调节。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Nayeli Aguilar-Hernández et al.
Viruses, 13(1) (2021-01-06)
Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8 enters human cells
A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Torpe N, et al.
Cell Reports, 26(12), 3183-3190 (2019)
Nanna Torpe et al.
Cell reports, 26(12), 3183-3190 (2019-03-21)
Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding
Ying Yuan et al.
Materials today. Bio, 21, 100697-100697 (2023-06-22)
Anastomotic thrombosis prevalently causes anastomosis failure, accompanied with ischemia and necrosis, the early diagnosis of which is restricted by inherent shortcomings of traditional imaging techniques in clinic and lack of appropriate prodromal biomarkers for thrombosis initiation. Herein, a fresh thrombus-specific
Suma Yarapureddy et al.
Neoplasia (New York, N.Y.), 21(6), 516-532 (2019-04-28)
Patients with metastatic or relapsed/refractory osteosarcoma (OS) have a 5-year survival rate of <30%. This has remained unchanged over several decades. One of the factors contributing to lack of improvement in survival is the development of chemoresistance. Hence, elucidating and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门