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Merck
CN
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安全信息

P0883

Sigma-Aldrich

聚(脱氧腺苷-胸苷)酸 钠盐

double-stranded alternating copolymer

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别名:
Poly(dA-dT) • Poly(dA-dT)
CAS号:
86828-69-5
MDL编号:
MFCD00131964
UNSPSC代码:
41106305
NACRES:
NA.51

质量水平

200

形式

powder

储存温度

−20°C

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应用

聚(脱氧腺苷-胸苷)（Poly(dA-dT) • Poly(dA-dT)）酸是用于DNA结构动力学和药物相互作用的构象研究的双链交替共聚物DNA模型。

其他说明

双链交替共聚物。

单位定义

一个酶活性单位是指在pH 7.0（1cm光程）条件下，在1.0 ml 20 mM磷酸钠/100 mM NaCl中产生1.0的A260 所需的酶量。

数量

1 mg相当于 ≥12 A260 单位。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. In what should Product P0883, Poly(deoxyadenylic-thymidylic) acid sodium salt, be dissolved?

    Per our supplier, to maintain a double stranded configuration of the polymer in solution, it should be rehydrated with a neutral buffer containing 100 mM NaCl.  After reconstitution, the polymer solution should be stored at -20°C.

  6. What is the difference between Poly(deoxyadenylic-thymidylic) acid sodium salt Products P0883 and P5782?

    Prod. No. P0883 is from a different supplier than Prod. No. P5782.  Chain lengths for both products can vary from batch to batch.  According to information from our suppliers, the A250/A260 ratios are similar, but the A280/A260 ratio for Prod. No. P0883 will be slightly higher than that of Prod. No. P5782.

  7. What is the sequence of Product P0883, Poly(deoxyadenylic-thymidylic) acid sodium salt?

    This product is a double-stranded alternating DNA copolymer, although it is possible for single strands to be present.  The sequence of each strand is an alternating sequence of dAdTdAdTdAdT….. or dATdATdATdAT… since dT (deoxythymidylic acid) and T (thymidylic acid) are the same.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 25(1), 77-84 (2007-08-07)
The thermal denaturation of the synthetic high molecular weight double stranded polynucleotide poly(dA-dT) x poly(dA-dT) has been studied in aqueous buffered solution (Tris 1.0 mM; pH 7.8+/-0.2) in the presence of increasing concentrations of either Ni(2+) (borderline cation) or Cd(2+)
M Vorlícková et al.
Journal of biomolecular structure & dynamics, 3(1), 67-83 (1985-08-01)
The article reviews data indicating that poly(dA-dT).poly(dA-dT) is able of adopting three distinct double helical structures in solution, of which only the A form conforms to classical notions. The other two structures have dinucleotides as double helical repeats. At low
Marta Airoldi et al.
Chirality, 20(9), 951-960 (2008-02-05)
The thermal behavior of the synthetic, high molecular weight, double stranded polynucleotides poly(dA-dT).poly(dA-dT) [polyAT] and poly(dG-dC).poly(dG-dC) [polyGC] solubilized in the aqueous core of the quaternary water-in-oil cationic microemulsion CTAB|n-pentanol|n-hexane|water in the presence of increasing amounts of NiCl(2) at several constant
Creina Slator et al.
ACS chemical biology, 11(1), 159-171 (2015-10-22)
The in cellulo catalytic production of reactive oxygen species (ROS) by copper(II) and iron(II) complexes is now recognized as a major mechanistic model in the design of effective cytotoxins of human cancer. The developmental complex, [Cu(o-phthalate)(1,10-phenanthroline)] (Cu-Ph), was recently reported
Natasha McStay et al.
Nucleic acids research, 45(2), 527-540 (2016-12-03)
Herein we report the synthesis of tripodal C
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