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安全信息

P4929

Sigma-Aldrich

聚脱氧肌苷酸-脱氧胞苷酸 钠盐

double-stranded alternating copolymer

别名:

Poly(dI-dC) • Poly(dI-dC) 钠盐

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About This Item

CAS号:
118578-37-3
MDL编号:
MFCD00131970
UNSPSC代码:
41106305
NACRES:
NA.51

生物来源

synthetic (organic)

质量水平

200

形式

powder

储存温度

−20°C

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应用

聚（脱氧肌苷 - 脱氧胞苷）酸钠盐已用于p65蛋白和neuro-2A蛋白裂解物的电泳迁移位移试验。它还被用作蛋白精氨酸甲基转移酶1（PRMT1）和DNA甲基转移酶1（DNMT1）选择性测定中的底物。
聚（脱氧肌苷 - 脱氧胞苷）酸钠盐已用于合成和表征双（2-（嘧啶-2-γl）乙氧基）烷烃及其药理活性的研究中。聚（脱氧肌苷 - 脱氧胞苷）酸钠盐也已用于研究碳酸钙薄膜在LB/LbL基质上生长。
聚（脱氧肌苷-脱氧胞苷）酸（聚（dI-dC）•聚（dI-dC））是可用作DNA底物的交替共聚物，其可用于评估DNA甲基转移酶（如DNA甲基转移酶1），以及作为双链DNA模型用于DNA结构动力学和药物、小分子、相互作用的构象研究。

生化/生理作用

聚（2′-脱氧肌苷-2′-脱氧胞苷酸），聚（dI-dC）是一种合成的DNA底物。在高盐下，Poly（dI-dC）以左旋螺旋构象存在，并在降低盐浓度过程中恢复为右旋形式。它可用于电泳迁移位移试验（EMSA）。

其他说明

双链交替共聚物

单位定义

在20mM磷酸钠/100mMNaCl(pH 7.0)缓冲液中，一个单位可在1.0ml中产生A260 = 1.0（1cm光程）

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. What is the molecular weight of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt?

    Molecular weight: Polymer size (by agarose gel electrophoresis) is lot dependent with a lower range of less than 150 to 550 base pairs and a high range of 3000 to over 5000 base pairs. Most of the material is between 1200 to 3000 base pairs.

  3. How many milligrams of Product P4929, Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, do I have?

    The specifications for the product is approximately 13 U/mg, but the exact amount is lot specific.  One unit will yield an A260 of 1.0 in 1.0ml of water.  For example, the 5 unit size has approximately 0.384 mg. 

  4. Is Is Product P4929,  Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC), stable in solution?

    Both the solution and solid are very stable and can be stored for extended periods (years) at -20 °C.

  5. What is the solubility of Is Product P4929,  Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(dI-dC)?

    This product is soluble in water or neutral buffer at 20 mg/ml.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Dimitrios Priftis et al.
Langmuir : the ACS journal of surfaces and colloids, 28(23), 8721-8729 (2012-05-15)
A systematic study of the interfacial energy (γ) of polypeptide complex coacervates in aqueous solution was performed using a surface forces apparatus (SFA). Poly(L-lysine hydrochloride) (PLys) and poly(L-glutamic acid sodium salt) (PGA) were investigated as a model pair of oppositely
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Workman A, et al.
Journal of Virology, 83(17), 8800-8809 (2009)
Meaghan L Clark et al.
Inorganic chemistry, 47(20), 9410-9418 (2008-09-25)
This paper focuses on DNA-binding interactions exhibited by Pt(dma-T)CN(+), where dma-T denotes 4'-dimethylamino-2,2':6',2''-terpyridine, and includes complementary studies of the corresponding pyrr-T complex, where pyrr-T denotes 4'-(N-pyrrolidinyl)-2,2':6',2''-terpyridine. The chromophores are useful for understanding the interesting and rather intricate DNA-binding interactions exhibited
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It has been known that ABA INSENSITIVE 5 (ABI5) plays a vital role in regulating seed germination. In the present study, we showed that inhibition of the catalase activity with 3-amino-1,2,4-triazole (3-AT) inhibits seed germination of Col-0, abi5 mutants and
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Ye F, et al.
Journal of Chemical Information and Modeling, 58(5), 1066-1073 (2018)
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