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用途
sufficient for 100 colorimetric or fluorometric tests
应用
pharmaceutical
检测方法
colorimetric
fluorometric
运输
dry ice
储存温度
−20°C
一般描述
神经氨酸酶，也称为唾液酸酶，是一种水解多糖链上末端唾液酸残基的酶。它主要在细菌和病毒等微生物中表达。据信神经氨酸酶切割唾液酸残基在流感病毒感染中起多种作用。人们认为它有助于粘膜衬里的渗透、靶细胞的入侵、子代病毒从感染细胞中的洗脱以及防止自聚集。因此，神经氨酸酶是流感药物开发的重要目标，用于测量神经氨酸酶活性的简单，直接和自动化的程序在研究和药物发现中得到了广泛的应用。
应用
- 5-Nitrobenzo[c][1, 2, 5]selenadiazole as therapeutic agents in the regulation of oxidative stress and inflammation induced by influenza A(H1N1)pdm09 in vitro and in vivo.: This research utilized the Neuraminidase Activity Assay Kit to explore therapeutic agents that regulate oxidative stress and inflammation, showcasing its crucial role in antiviral research and potential pharmacological applications (Guo et al., 2023).
- Potency of bacterial sialidase Clostridium perfringens as antiviral of Newcastle disease infections using embryonated chicken egg in ovo model.: Highlights the kit′s use to measure and observe sialidase enzyme activity to assess the antiviral potential of bacterial enzymes against poultry diseases, contributing to the development of novel biocontrol methods (Kurnia et al., 2022).
- Molecular Docking Studies and Biological Evaluation of Berberine-Benzothiazole Derivatives as an Anti-Influenza Agent via Blocking of Neuraminidase.: Utilizes neuraminidase assay kit to evaluate the efficacy of synthesized compound′s neuraminidase activity, offering a path towards the design of new antiviral drugs with enhanced specificity and potency (Kumar et al., 2021).
特点和优势
兼容高通量的操作系统。
适用性
适用于生物样品中的神经氨酸酶活性检测，可用于筛选神经氨酸酶抑制剂。
原理
在该测定中，神经氨酸酶活性通过酶促测定法测定，其中神经氨酸酶释放的唾液酸产生与样品中神经氨酸酶活性成正比的比色（570 nm）/荧光（λex = 530/λem = 585 nm）产物。在37°C下的线性检测范围对于比色测定为0.1-10单位/L，对于荧光测定为0.01-2单位/L。
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
法规信息
含少量动物源组分生物产品
常规特殊物品
Rose T Byrne-Nash et al.
NPJ vaccines, 4, 3-3 (2019-01-25)
Neuraminidase (NA) immunity leads to decreased viral shedding and reduced severity of influenza disease; however, NA content in influenza vaccines is currently not regulated, resulting in inconsistent quality and quantity of NA that can vary from manufacturer to manufacturer, from
Aurora Salamanca et al.
Antiviral chemistry & chemotherapy, 29, 20402066211063391-20402066211063391 (2021-11-30)
Seasonal flu is caused by influenza infection, a virus that spreads easily in human population with periodical epidemic outbreaks. The high mutational rate of influenza viruses leads to the emergence of strains resistant to the current treatments. Due to that
Irene Gómez Delgado et al.
Frontiers in immunology, 12, 641656-641656 (2021-03-30)
Haemolytic Uraemic Syndrome associated with Streptococcus pneumoniae infections (SP-HUS) is a clinically well-known entity that generally affects infants, and could have a worse prognosis than HUS associated to E. coli infections. It has been assumed that complement genetic variants associated
Alfred T Harding et al.
mBio, 8(3) (2017-06-08)
Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of
Laura R Kuck et al.
Vaccine, 36(21), 2937-2945 (2018-04-28)
Practical methods to measure the potency of influenza vaccines are needed as alternatives for the standard single radial immunodiffusion (SRID) assay. VaxArray assays for influenza hemagglutinin (HA) and neuraminidase (NA) have been developed to address this need. In this report
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