所有图片(1)
别名:
1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
经验公式（希尔记法）:
C15H22N2O · HCl
推荐产品
Agency
meets USP testing specifications
检测方案
98.0-102.0%
创始人
Novocol
SMILES字符串
CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl
InChI
1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
InChI key
RETIMRUQNCDCQB-UHFFFAOYSA-N
基因信息
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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生化/生理作用
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novocol. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - STOT SE 3
靶器官
Central nervous system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
Hui-Jin Sung et al.
Canadian journal of physiology and pharmacology, 90(7), 863-872 (2012-06-19)
Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and
Mi Hyeon Lee et al.
Pain medicine (Malden, Mass.), 13(11), 1381-1388 (2012-09-28)
Compared with the blind technique, ultrasound-guided stellate ganglion block (SGB) reduces the amount of local anesthetic needed for a successful block. The purpose of this study is to determine the minimal, optimal volume of local anesthetic required for successful ultrasound-guided
D Van Vynckt et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 25(4), 307-313 (2012-06-15)
Assessment of the effect of intra-articular anaesthesia on lameness caused by medial coronoid disease. This study included 90 dogs that were evaluated for the complaint of unilateral forelimb lameness. All dogs were suspected of having an elbow problem for which
Jeff Gadsden et al.
Anesthesia and analgesia, 115(4), 963-967 (2012-07-17)
During peripheral nerve blockade, different local anesthetics may be sequentially administered. Typically, a short- or intermediate-acting local anesthetic is administered before a long-acting local anesthetic to achieve a block with rapid onset and long duration. However, there is a paucity
Kaoru Hara et al.
Regional anesthesia and pain medicine, 37(3), 289-293 (2012-04-06)
The present study was conducted to determine the incidence of unintentional intraneural injection during ultrasound-guided subgluteal sciatic nerve block using a low-frequency transducer. We also observed the effects of intraneural injection using ropivacaine and mepivacaine. Enrolled in the study were
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