I7379
丙米嗪 盐酸盐
≥99% (TLC), powder, selective serotonin reuptake inhibitor
别名:
10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H24N2 · HCl
化学文摘社编号:
分子量:
316.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
产品名称
丙米嗪 盐酸盐, ≥99% (TLC)
InChI key
XZZXIYZZBJDEEP-UHFFFAOYSA-N
InChI
1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
assay
≥99% (TLC)
form
powder
color
white
solubility
H2O: 50 mg/mL
originator
Novartis
Quality Level
Gene Information
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Biochem/physiol Actions
三环类抗抑郁药；抑制 5-羟色胺和去甲肾上腺素转运蛋白；对多巴胺转运蛋白影响很小。
三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 Ki 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（Ki = 25 μM）。
Application
Imipramine hydrochloride has been used:
- as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
- to investigate its interaction with insulin in aqueous solution
- to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification
Features and Benefits
This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Thermodynamic study of the imipramine-insulin interaction
Lopez-Fontan J, et al.
The Journal of Chemical Thermodynamics, 31(10), 1297-1306 (1999)
Attention Deficit Hyperactivity Disorder
Comprehensive Medicinal Chemistry II.: Global perspective (2007)
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Willnow TE, et al.
Test, 267(36), 26172-26180 (1992)
Direct retino-raphe projection alters serotonergic tone and affective behavior
Ren C, et al.
Neuropsychopharmacology, 38(7), 1163-1163 (2013)
Psychotropic drugs
Drugs During Pregnancy and Lactation, 743-774 (2015)
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