跳转至内容
Merck
CN
所有图片(3)

主要文件

查看所有文档

安全信息

I7379

Sigma-Aldrich

丙米嗪 盐酸盐

≥99% (TLC), powder, antidepressant

别名:

10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐

登录查看公司和协议定价
所有图片(3)

About This Item

经验公式（希尔记法）:
C19H24N2 · HCl
CAS号:
113-52-0
分子量:
316.87
EC 号:
204-030-7
MDL编号:
MFCD00012669
UNSPSC代码:
12352116
PubChem化学物质编号:
24278097
NACRES:
NA.77

产品名称

丙米嗪 盐酸盐, ≥99% (TLC)

质量水平

200

方案

≥99% (TLC)

表单

powder

颜色

white

溶解性

H2O: 50 mg/mL

创始人

Novartis

SMILES字符串

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A2(6530) , SLC6A4(6532)

正在寻找类似产品? 访问 产品对比指南

一般描述

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

应用

Imipramine hydrochloride has been used:
  • as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
  • to investigate its interaction with insulin in aqueous solution
  • to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

生化/生理作用

三环类抗抑郁药；抑制 5-羟色胺和去甲肾上腺素转运蛋白；对多巴胺转运蛋白影响很小。
三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 Ki 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（Ki = 25 μM）。

特点和优势

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000323374
0000323375
0000323373
0000317041
0000317040

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Willnow TE, et al.
Test, 267(36), 26172-26180 (1992)
Attention Deficit Hyperactivity Disorder
Comprehensive Medicinal Chemistry II.: Global perspective (2007)
Thermodynamic study of the imipramine-insulin interaction
Lopez-Fontan J, et al.
The Journal of Chemical Thermodynamics, 31(10), 1297-1306 (1999)
Psychotropic drugs
Drugs During Pregnancy and Lactation, 743-774 (2015)
Yeqing Huang et al.
Biochemical and biophysical research communications, 518(2), 337-343 (2019-08-20)
The slow onset of traditional antidepressants has become an urgent clinical issue, researchers are constantly exploring new antidepressants with prompt action. Previous studies have found that zinc levels were decreased in serum and brain of depressed patients or animal models.
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门