product name
5-氟脲嘧啶, ≥99% (HPLC), powder
质量水平
检测方案
≥99% (HPLC)
形式
powder
颜色
white
mp
282-286 °C (dec.) (lit.)
溶解性
1 M NH4OH: soluble
DMSO/DMF: soluble
methanol: soluble
εmax
7.07 at 265 nm in 0.1 M HCl
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
基因信息
human ... TYMS(7298)
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应用
生化/生理作用
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Carc. 2
WGK
WGK 3
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is Product F6627, 5-Fluorouracil, sterile?
No. No sterility or endotoxin testing has been performed. Solutions of the product can be sterile filtered before use.
Products F6627 and 47576 are stated to have 99% purity. What are the differences between the two 5-fluorouracil products?
The purity of Product No. F6627 is determined by TLC (thin layer chromatography). The purity of deleted product 47576 was determined by HPLC (high performance liquid chromatography).
I see that Product F6627, 5-Fluorouracil, is soluble at a concentration of 50 mg/mL in 1M ammonium hydroxide. Do you have any information regarding the solubility in water?
Although product F6627 is not tested for solubility in water, there should be some limited solubility. Product 47576 has been tested at 10 mg/mL in water, although heat had to be applied. Upon cooling it might be possible to observe some precipitation. No testing in water is performed at Sigma on a lot to lot basis. The product is more soluble at higher alkaline pH.
Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
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