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主要文件

O9512

Sigma-Aldrich

奥沙利铂

powder

别名:

[SP-4-2-(1R-反式)]-(1,2-环己二胺-N,N′)[乙二酸(2-)-O,O’]铂

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100 MG
¥436.96
500 MG
¥806.88
1 G
¥1,414.93
5 G
¥3,556.40
10 G
¥7,385.62
25 G
¥15,356.17

¥436.96


国内现货,预计发货时间2025年4月24日详情


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选择尺寸

变更视图
100 MG
¥436.96
500 MG
¥806.88
1 G
¥1,414.93
5 G
¥3,556.40
10 G
¥7,385.62
25 G
¥15,356.17

About This Item

经验公式(希尔记法):
C8H14N2O4Pt
CAS号:
分子量:
397.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

¥436.96


国内现货,预计发货时间2025年4月24日详情


获取大包装报价

表单

powder

质量水平

创始人

Sanofi Aventis

储存温度

2-8°C

SMILES字符串

O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChI key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

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P3125P5306P3375
technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

technique(s)

-

technique(s)

-

technique(s)

-

specific activity

≥10 units/mg protein

specific activity

≥16 units/mg protein

specific activity

≥8.0 units/mg protein

specific activity

1.5-10 units/mg solid

form

lyophilized powder

form

buffered aqueous suspension

form

lyophilized powder

form

crude powder

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

application(s)

-

mol wt

23.4 kDa

mol wt

23.4 kDa

mol wt

23.4 kDa

mol wt

23.4 kDa

应用

奥沙利铂已被用于:
  • 通过细胞活力测定,作为结肠直肠腺癌 SW480 细胞中的化学治疗剂[1]
  • 用于通过 MTT 比色法监测肝细胞癌 HepG2 和 HepG2/R 细胞中的细胞存活率[2]
  • 确定对人乳腺癌 MDA-MB-231 细胞的生长抑制作用[3]

生化/生理作用

奥沙利铂是一种铂类似物,通过结合 DNA 并形成链间和链内交联,阻止复制和转录,进而导致 DNA 损伤和细胞死亡。[1]奥沙利铂是一种具有抗结直肠癌活性的抗肿瘤药物;细胞毒性随着与 DNA 的加合物的形成而产生。奥沙利铂是用于治疗结直肠癌的已批准药物。[4]它是 FOLFOX(亚叶酸:5-FU:奥沙利铂,其比例分别为 1:10:1 的微摩尔浓度)中的活性成分。[3][5]奥沙利铂在患者中引起急性和慢性神经毒性(以剂量依赖性方式),并且通过减少或停止药物是可逆的。[4]

特点和优势

该化合物是 ADME Tox 和细胞凋亡研究的特色产品。发现更多 ADME Tox凋亡的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm
该化合物是由 Sanofi Aventis开发。如需浏览其他药物开发的化合物和批准的药物/候选药物清单,请单击此处

象形图

Health hazardCorrosion

警示用语:

Danger

危险分类

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    4. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    5. What is the solubility of Product O9512, Oxaliplatin?

      Sigma-Aldrich tests solubility of Product O9512, Oxaliplatin, in water at a concentration of 5 mg/ml. For complete dissolution, heating to 45 °C and sonication for 10 minutes may be required.

    6. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Expression of an oncogenic BARD1 splice variant impairs homologous recombination and predicts response to PARP-1 inhibitor therapy in colon cancer
    Ozden O, et al.
    Scientific Reports, 6, 26273-26273 (2016)
    Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue
    Jamieson SMF, et al.
    Molecular Pain, 5(1), 66-66 (2009)
    SUMOylation alterations are associated with multidrug resistance in hepatocellular carcinoma
    Qin Y, et al.
    Molecular Medicine Reports, 9(3), 877-881 (2014)
    Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study
    Votanopoulos KI, et al.
    Annals of Surgical Oncology, 1-9 (2018)
    S M E Engelen et al.
    European journal of cancer (Oxford, England : 1990), 49(10), 2311-2320 (2013-04-11)
    The purpose of this multicenter cohort study was to evaluate whether a differentiated treatment of primary rectal cancer based on magnetic resonance imaging (MRI) can reduce the number of incomplete resections and local recurrences and improve recurrence-free and overall survival.

    商品

    DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

    DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

    Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

    Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

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