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Merck
CN
所有图片(1)

主要文件

232120

Sigma-Aldrich

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

别名:

顺铂

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100 μL
CN¥4,239.58

CN¥4,239.58

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变更视图
100 μL
CN¥4,239.58

About This Item

线性分子式:
Pt(NH3)2Cl2
CAS号:
15663-27-1
MDL编号:
MFCD00011623
UNSPSC代码:
12352200
NACRES:
NA.77

CN¥4,239.58

请联系客服了解存货情况
新价格，新优惠！
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产品名称

顺铂, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

质量水平

100

描述

Merck USA index - 14, 2317

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

yellow

溶解性

PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL

运输

ambient

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查看完整比较结果

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1 of 4

此商品
557324B9934G9420
利鲁唑 solid

R116

利鲁唑

Riluzole A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.

557324

Riluzole

BTA-1 ≥98% (HPLC), solid

B9934

BTA-1

GNF-2 ≥98% (HPLC), solid

G9420

GNF-2

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

originator

Sanofi Aventis

originator

-

originator

-

originator

-

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1g(24768)

Gene Information

-

Gene Information

human ... APP(351)

Gene Information

-

一般描述

具有强效抗肿瘤活性的铂配位复合物。诱导癌细胞中的凋亡，可能通过caspase-3激活。据报道可使胶质瘤细胞对TNF-α-诱导的凋亡敏感。

注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。

生化/生理作用

主要靶标
诱导癌细胞凋亡
产物不与ATP竞争。
可逆：否
细胞渗透性：否

警告

毒性：有毒 & 致癌/致畸性（G）

重悬

溶液中不稳定；仅在使用前进行复溶。

其他说明

Hall, M.D., et al. 2014.Cancer Res. In press.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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    Laura Torresano et al.
    Oncogenesis, 11(1), 24-24 (2022-05-10)
    Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint inhibitors. Although metabolic enzymes offer additional targets for therapy, the precise metabolic proteome of lung adenocarcinomas is unknown, hampering its
    Jinan Li et al.
    Frontiers in molecular neuroscience, 15, 835448-835448 (2022-03-01)
    Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin. In zebrafish, the functional mechanotransduction channel is
    Adib Behrouzi et al.
    International journal of molecular sciences, 23(3) (2022-02-16)
    Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject
    Nada F Abo El-Magd et al.
    International journal of molecular sciences, 22(19) (2021-10-14)
    Renal toxicity is a serious side effect that hinders the use of cisplatin, a commonly used and effective chemotherapeutic agent. Meanwhile, quinacrine is an FDA approved drug that has been stated for its anti-inflammatory effect. Thus, we investigated the ameliorative
    Shruthi Sriramkumar et al.
    Journal of translational medicine, 20(1), 246-246 (2022-06-02)
    Platinum based agents-cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal. Platinum treatment enriches for chemoresistant aldehyde
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