推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
yellow
溶解性
PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/2Cl.2H3N.Pt/h;;2*1H3;
InChI key
JFUARQHXOQHNLK-UHFFFAOYSA-N
一般描述
具有强效抗肿瘤活性的铂配位复合物。
注：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
注：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
具有强效抗肿瘤活性的铂配位复合物。诱导癌细胞中的凋亡，可能通过caspase-3激活。据报道可使胶质瘤细胞对TNF-α-诱导的凋亡敏感。
注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
生化/生理作用
主要靶标
诱导癌细胞凋亡
诱导癌细胞凋亡
产物不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：有毒 & 致癌/致畸性（G）
重悬
溶液中不稳定；仅在使用前进行复溶。
其他说明
Hall, M.D., et al. 2014.Cancer Res. In press.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject
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