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F5631

Sigma-Aldrich

褐藻糖胶 来源于墨角藻

Crude

别名:

褐藻糖胶

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

algae (Fucus Vesiculosus)

质量水平

表单

powder

质量

Crude

颜色

light yellow to brown

溶解性

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

痕量阳离子

Ca: ≤1%
Na: ≤ 8% (ICP)

储存温度

room temp

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一般描述

褐藻糖胶是一种富含岩藻糖的硫酸多糖,从几种棕色海藻分离而来。

应用

来自 墨角藻 的褐藻糖胶可用作生物反应调节剂,也可作为具有广泛生物活性的潜在治疗剂。它作为一种潜在的抗癌、抗免疫和抗炎剂,可用于研究其药代动力学、安全性、有效性和给药方法。褐藻糖胶还可用于评估其组织工程应用的潜力和配方。

生化/生理作用

对褐藻糖胶的研究发现它具有广泛的生物活性,包括抗肿瘤和抗血管生成活性、免疫调节、抗炎、抗凝血、抗血栓形成和抗氧化活性。 褐藻糖胶诱导巨噬细胞活化,随后激活促分裂原活化蛋白激酶(MAPK),并导致自然杀伤细胞增殖。 褐藻糖胶作为非选择性选择素阻断剂起作用,已被证明可诱导细胞凋亡并抑制血管生成。

制备说明

通过修改 Black,W.a.P. 等人编写的 农业食品行业期刊第122期(1952年)第3页的方法制备。

其他说明

为了全面了解我们针对客户研究提供的各种多糖产品,建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the molecular weight of Product F5631, Fucoidan from Fucus vesiculosus?

    The molecular weight of the F5631 is assayed on a lot-by-lot basis. The molecular weight will be reported on the certificate of analysis for each lot of product.

  7. What is the solubility of Product F5631, Fucoidan from Fucus vesiculosus?

    The F5631 is water-soluble. It is tested for solublity in water at 10mg/mL; this yields a clear to hazy, yellow to amber solution.

  8. What is the purity of Product F5631, Fucoidan from Fucus vesiculosus?

    The F5631 is not tested for purity or to identify possible impurities. It is a crude fucoidan from Fucus vesiculosus.

  9. Is there information about the structure of Product F5631, Fucoidan from Fucus vesiculosus?

    In general, fucoidin is a branched polymer of L-fucose monosulfate joined predominately by 1,2 linkages. Fucoidin is also known in the literature as fucan. The properties are discussed further by Bernardi and Springer in J. Biol. Chem, 237, 75-80 (1962); the title of the article is "Properties of highly purified fucan".

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Celina Maria P Guerra Dore et al.
Carbohydrate polymers, 91(1), 467-475 (2012-10-10)
Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate
Suwaree Kitikiew et al.
Fish & shellfish immunology, 34(1), 280-290 (2012-12-04)
In this study, we examined the effect of fucoidan on the immune response of white shrimp Litopenaeus vannamei and its resistance against Vibrio alginolyticus infection. Fucoidan induced degranulation, caused changes in the cell morphology, and increased activation of prophenoloxidase (proPO)
A M Walsh et al.
The British journal of nutrition, 110(9), 1630-1638 (2013-03-28)
A 2 × 2 factorial experiment was conducted to investigate the interactions between laminarin (LAM; 0 and 300 parts per million (ppm)) and fucoidan (FUC; 0 and 240 ppm) levels on intestinal morphology, selected microbiota and inflammatory cytokine gene expression
Weihua Jin et al.
Carbohydrate polymers, 91(1), 1-6 (2012-10-10)
Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these
Jean-Marc Alsac et al.
Journal of vascular surgery, 57(3), 796-805 (2012-11-13)
Neutrophils have been shown to be involved in all stages of human and experimental abdominal aortic aneurysm (AAA) development. The initial processes of neutrophil rolling and trapping in the intraluminal thrombus (ILT) are mediated mainly by P-selectin expressed by activated

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