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F5631

Sigma-Aldrich

褐藻糖胶 来源于墨角藻

Crude

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别名:
褐藻糖胶
CAS号:
9072-19-9
MDL编号:
MFCD00131109
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

algae (Fucus Vesiculosus)

质量水平

200

形式

powder

质量

Crude

颜色

light yellow to brown

溶解性

H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow

痕量阳离子

Ca: ≤1%
Na: ≤ 8% (ICP)

储存温度

room temp

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相关类别

一般描述

褐藻糖胶是一种富含岩藻糖的硫酸多糖，从几种棕色海藻分离而来。

应用

来自 墨角藻 的褐藻糖胶可用作生物反应调节剂，也可作为具有广泛生物活性的潜在治疗剂。它作为一种潜在的抗癌、抗免疫和抗炎剂，可用于研究其药代动力学、安全性、有效性和给药方法。褐藻糖胶还可用于评估其组织工程应用的潜力和配方。

生化/生理作用

对褐藻糖胶的研究发现它具有广泛的生物活性，包括抗肿瘤和抗血管生成活性、免疫调节、抗炎、抗凝血、抗血栓形成和抗氧化活性。 褐藻糖胶诱导巨噬细胞活化，随后激活促分裂原活化蛋白激酶（MAPK），并导致自然杀伤细胞增殖。 褐藻糖胶作为非选择性选择素阻断剂起作用，已被证明可诱导细胞凋亡并抑制血管生成。

制备说明

通过修改 Black,W.a.P. 等人编写的 农业食品行业期刊第122期（1952年）第3页的方法制备。

其他说明

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the molecular weight of Product F5631, Fucoidan from Fucus vesiculosus?

    The molecular weight of the F5631 is assayed on a lot-by-lot basis. The molecular weight will be reported on the certificate of analysis for each lot of product.

  7. What is the solubility of Product F5631, Fucoidan from Fucus vesiculosus?

    The F5631 is water-soluble. It is tested for solublity in water at 10mg/mL; this yields a clear to hazy, yellow to amber solution.

  8. What is the purity of Product F5631, Fucoidan from Fucus vesiculosus?

    The F5631 is not tested for purity or to identify possible impurities. It is a crude fucoidan from Fucus vesiculosus.

  9. Is there information about the structure of Product F5631, Fucoidan from Fucus vesiculosus?

    In general, fucoidin is a branched polymer of L-fucose monosulfate joined predominately by 1,2 linkages. Fucoidin is also known in the literature as fucan. The properties are discussed further by Bernardi and Springer in J. Biol. Chem, 237, 75-80 (1962); the title of the article is "Properties of highly purified fucan".

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Structure of fucoidan from sea cucumber Acaudina molpadioides (Am-FUC) was investigated in this study. Low molecular weight polysaccharide of Am-FUC (Am-LMW) was prepared by enzymatic degradation and assayed by nuclear magnetic resonance. According to the structure of Am-LMW, and referring
Wei Wang et al.
Marine drugs, 10(12), 2795-2816 (2012-12-14)
Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety
Kazuo Azuma et al.
Marine drugs, 10(10), 2337-2348 (2012-11-22)
We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5-40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110-138 kDa) and high-molecular-weight fucoidan (HMWF:
Yong-Seok Han et al.
Marine drugs, 17(9) (2019-09-05)
Mitochondria are considered to be the powerhouses of cells. They are the most commonly damaged organelles within dopaminergic neurons in patients with Parkinson's disease (PD). Despite the importance of protecting neuronal mitochondria in PD patients, the detailed mechanisms underlying mitochondrial
Olesya S Vishchuk et al.
Food chemistry, 141(2), 1211-1217 (2013-06-26)
The sulfated polysaccharides from brown algae - the fucoidans - are known to be a topic of numerous studies, due to their beneficial biological activities including anti-tumour activity. In this study the effect of fucoidans isolated from brown algae Saccharina
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