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F132

Sigma-Aldrich

氟西汀 盐酸盐

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

别名:

氟西汀 HCl, (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯丙胺 盐酸盐, LY-110,140 盐酸盐, Prozac®

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About This Item

经验公式（希尔记法）:
C17H18F3NO · HCl
CAS号:
56296-78-7
分子量:
345.79
EC 号:
260-101-2
MDL编号:
MFCD00214288
UNSPSC代码:
12352200
PubChem化学物质编号:
24278096
NACRES:
NA.77

产品名称

氟西汀 盐酸盐, solid

表单

solid

质量水平

200

颜色

white

溶解性

H2O: 4 mg/mL
DMSO: >5 mg/mL

创始人

Eli Lilly

SMILES字符串

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

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一般描述

盐酸氟西汀是一种精神类药物，是最早的抗抑郁药物之一，是选择性血清素再摄取抑制剂。它是百忧解有效成分之一。®

应用

盐酸氟西汀可以用于研究它对于小鼠放射药物 123I-标记2-（（2-（（二甲基氨基）甲基）苯基）硫基）-5-碘苯基胺([123I]ADAM)和SERT（血清素载体）结合的作用。它也被用于长期治疗缺乏光线的动物。它还被用作血清素再摄取抑制剂，以研究其对鱼类急性应激的影响。

生化/生理作用

盐酸氟西汀作用于突触前末梢，它能够避免血清素再摄取，导致突触细胞外液体中血清素积累。
选择性羟色胺再摄取抑制剂；抗抑郁剂。

特点和优势

该化合物是ADME Tox和胞凋亡研究的特色产品。发现更多的ADME Tox和细胞凋亡特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物是由 Eli Lilly研发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
该化合物被记录在受体分类和信号传导手册生物胺转运蛋白和氯化物通道网页上。想要浏览手册的其他页面， 请单击此处。

法律信息

经 Eli Lilly and Company 授权销售。
Prozac is a registered trademark of Eli Lilly and Co.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000350780
0000350782
0000334880
0000290043
0000290043

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Natural environments are subject to a range of anthropogenic stressors, with pharmaceutical pollution being among the fastest-growing agents of global change. However, despite wild animals living in complex multi-stressor environments, interactions between pharmaceutical exposure and other stressors remain poorly understood.
T Frisan et al.
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Epstein-Barr virus (EBV)-positive Hodgkin's and Reed-Sternberg (HRS) cells express the virus-encoded latent membrane proteins LMP1 and LMP2 that could serve as rejection targets in Hodgkin's disease (HD). To examine whether EBV-triggered reactivities can be detected in the tumor, we have
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Stress is known to modulate behavioral responses and rapid decision-making processes, especially under challenging contexts which often occur in social and cooperative interactions. Here, we evaluated the effects of acute stress on cooperative behavior of the Indo-Pacific cleaner wrasse (Labroides
Xin-Xian Ye et al.
Nuclear medicine and biology, 31(5), 557-562 (2004-06-29)
A radiopharmaceutical, (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([(123)I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor
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Chromatograms

application for HPLCsuitable for GC

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