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E9156

Sigma-Aldrich

Encainide 盐酸盐

≥98% (HPLC), powder

别名:

(+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide 盐酸盐, MJ-9067

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About This Item

经验公式（希尔记法）:
C22H28N2O2 · HCl
CAS号:
66794-74-9
分子量:
388.93
MDL编号:
MFCD01667688
UNSPSC代码:
12352200
PubChem化学物质编号:
329799083
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

溶解性

H2O: >25 mg/mL

创始人

Bristol-Myers Squibb

储存温度

2-8°C

SMILES字符串

Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C

InChI

1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

InChI key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

生化/生理作用

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic.
Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.

特点和优势

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
018K46111
018K4611

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R W Peters et al.
Journal of the American College of Cardiology, 23(2), 283-289 (1994-02-01)
The purpose of this study was to assess the effect of antiarrhythmic drugs on the timing of arrhythmic death. Sudden cardiac death remains a problem of epidemic proportions. Delineating its pathophysiology is an important step in devising preventive measures. Previous
A A Wallace et al.
Journal of cardiovascular pharmacology, 21(3), 397-404 (1993-03-01)
The antiarrhythmic efficacy and proarrhythmic potential of the class IC antiarrhythmic agent encainide were assessed in subacute and chronic postinfarction canine models, respectively. In conscious dogs with spontaneous premature ventricular complexes (PVCs) at 48 h after anterior myocardial infarction (MI)
J L Anderson et al.
Circulation, 90(6), 2843-2852 (1994-12-01)
The Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death. Patients in whom ventricular ectopy could be suppressed with
A P Hallstrom et al.
American heart journal, 130(1), 71-79 (1995-07-01)
In this study we investigated the time to the first arrhythmic, ischemic, or failure event for encainide-flecainide and moricizine versus their respective placebo comparison groups in the Cardiac Arrhythmia Suppression Trial. The purpose was to explore possible mechanisms for the
R J Sweeney et al.
Pacing and clinical electrophysiology : PACE, 19(1), 50-60 (1996-01-01)
The mechanisms by which pharmacological agents alter electrical defibrillation are not fully understood. It has been proposed that, in addition to directly stimulating tissue, defibrillation may involve refractory period extension (RPE) produced by the shock. Accordingly, pharmacological agents might modulate
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