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Merck
CN

E9156

Encainide 盐酸盐

≥98% (HPLC), powder

别名:

(+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide 盐酸盐, MJ-9067

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关于此项目

经验公式（希尔记法）:
C22H28N2O2 · HCl
化学文摘社编号:
66794-74-9
分子量:
388.93
NACRES:
NA.77
PubChem Substance ID:
329799083
UNSPSC Code:
12352200
MDL number:
MFCD01667688

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InChI key

OJIIZIWOLTYOBS-UHFFFAOYSA-N

SMILES string

Cl.COc1ccc(cc1)C(=O)Nc2ccccc2CCC3CCCCN3C

InChI

1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

assay

≥98% (HPLC)

form

powder

solubility

H2O: >25 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Biochem/physiol Actions

Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic.
Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
018K46111
018K4611

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H J Duff et al.
The Journal of pharmacology and experimental therapeutics, 274(1), 508-515 (1995-07-01)
Encainide treatment in patients after myocardial infarction is associated with increased risk of sudden cardiac death. This may relate to drug-induced changes in the electrophysiologic milieu, thus predisposing the patient to sustained ventricular tachyarrhythmias. The goals of this study were
J C Kellen et al.
American journal of critical care : an official publication, American Association of Critical-Care Nurses, 5(1), 19-25 (1996-01-01)
Care of patients with ventricular arrhythmia after myocardial infarction requires careful nursing management, including assisting with arrhythmia monitoring and testing. Because ventricular premature depolarization is a known risk factor for sudden cardiac death, it was hypothesized that the suppression of
A E Epstein et al.
JAMA, 270(20), 2451-2455 (1993-11-24)
To test the hypothesis that in survivors of myocardial infarction, the suppression of ventricular premature depolarizations improves survival free of cardiac arrest and arrhythmic death. International, prospective, multicenter, randomized, placebo-controlled trial. University and community hospitals. A total of 3549 patients
S Goldstein et al.
Circulation, 91(1), 79-83 (1995-01-01)
We tested the hypothesis that patients whose ventricular arrhythmias are easy to suppress have a lower rate of arrhythmic death, defined as arrhythmic death and nonfatal cardiac arrest, the primary end point in the Cardiac Arrhythmia Suppression Trials (CAST-I and
W Jung et al.
Pacing and clinical electrophysiology : PACE, 16(4 Pt 1), 778-788 (1993-04-01)
In a prospective study the efficacy of amiodarone in combination with the three Class I drugs mexiletine, flecainide, or encainide was evaluated consecutively in 12 patients with recurrent ventricular tachycardias (VT) by programmed stimulation. None of the tested drug combinations
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商品

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

钠通道

电压门控钠通道存在于大多数可兴奋细胞膜中，在产生动作电位方面起着重要作用。

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