推荐产品
生物来源
human urine
质量水平
无菌性
aseptically processed
形式
lyophilized powder
效能
≥5,000 I.U. per mg
分子量
37.9 kDa
apparent mol wt 37.9 kDa by SDS-PAGE
drug control
Home Office Schedule 4.2
技术
cell culture | embryo: suitable
杂质
HBV,HCV and HIV, tested negative
溶解性
H2O: 1 mL/vial
saline: 1 mL/vial
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CGA(1081)
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一般描述
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
注意：根据糖基化程度的不同，实际分子量与理论值不同。该物质天然形式的理论分子量为 37.9kDa，且包含 2 个亚基：α = 14.9kDa（多肽部分 ~10.2kDa，碳水化合物部分 ~4.7kDa），β = 23.0kDa（多肽部分 ~16.0kDa，碳水化合物部分 ~7.0kDa）。参见 J. Biol. Chem. 248，6796-6827(1973)。
应用
推荐用于小鼠的超数排卵诱导。
生化/生理作用
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Genetic-engineered models of skeletal diseases. II. Targeting mutations into transgenic mice chondrocytes.
S Garofalo et al.
Methods in molecular biology (Clifton, N.J.), 137, 491-498 (2000-08-19)
Zheng Zhang et al.
The Journal of reproduction and development, 55(1), 94-97 (2008-11-22)
Embryos transfer is one of the most critical steps for generating genetically modified mice. Because of the limitations of the current transfer equipment and techniques, such as discharge of freshly transferred embryos and the necessity of sophisticated transfer skills, the
Geetika Bassi et al.
iScience, 25(4), 104165-104165 (2022-04-19)
Mitochondria are essential for steroidogenesis. In steroidogenic cells, the initiation of steroidogenesis from cholesterol occurs on the matrix side of the inner mitochondrial membrane by the enzyme P450scc. This requires cholesterol import from the cytoplasm through the outer mitochondrial membrane
Manyu Li et al.
Biology of reproduction, 79(6), 1169-1175 (2008-08-22)
Adrenomedullin (AM) is a multifunctional peptide vasodilator that signals through a G-protein-coupled receptor when the receptor, called calcitonin receptor-like receptor (CL), is associated with a receptor activity-modifying protein 2 (RAMP2). We demonstrated previously that haploinsufficieny for each of these genes
Styliani Markoulaki et al.
Methods (San Diego, Calif.), 45(2), 101-114 (2008-07-03)
Addressing the fundamental questions of nuclear equivalence in somatic cells has fascinated scientists for decades and has resulted in the development of somatic cell nuclear transfer (SCNT) or animal cloning. SCNT involves the transfer of the nucleus of a somatic
商品
Mouse embryo media and embryo validated reagents for transgenic mouse embryo culture
用于转基因小鼠胚胎培养的小鼠胚胎培养基及经过胚胎培养验证的试剂
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