CG5
绒毛膜促性腺激素 人
lyophilized powder, vial of ~5,000 IU
别名:
HCG, 绒毛膜促性腺激素
产品名称
绒毛膜促性腺激素 人, lyophilized powder, vial of ~5,000 IU
biological source
human urine
sterility
sterile-filtered
form
lyophilized powder
mol wt
37.9 kDa
contains
mannitol
packaging
vial of ~5,000 IU
drug control
Home Office Schedule 4.2
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
solubility
water: 10 mL/vial, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... CGA(1081)
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General description
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG. CGA is mapped to human chromosome 6q14.3. hCG comprises of α and β chain.
Analysis Note
The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.
Application
Chorionic gonadotropin human has been used:
- to induce oocyte maturation in cultured follicles
- along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
- as medium component for fetal testes culture to aid steroidogenic responsiveness
Biochem/physiol Actions
Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.
Preparation Note
When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.02 M sodium phosphate buffer (pH approx. 7.2) and 20 mg/mL of mannitol.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
LH and the Male
Human Chorionic Gonadotropin (2018)
Endocrine disruption in human fetal testis explants by individual and combined exposures to selected pharmaceuticals, pesticides, and environmental pollutants
Gaudriault P, et al.
Environmental Health Perspectives, 125(8), 087004-087004 (2017)
Comparison of the oocyte quality derived from two-dimensional follicle culture methods and developmental competence of in vitro grown and matured oocytes
Lee J, et al.
BioMed Research International, 2018 (2018)
Following the course of pre-implantation embryo patterning by non-linear microscopy
Kyvelidou C, et al.
Journal of Structural Biology, 176(3), 379-386 (2011)
Candidate epitopes for measurement of hCG and related molecules: the second ISOBM TD-7 workshop
Berger P, et al.
Tumor Biology, 34(6), 4033-4057 (2013)
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