C7861
氢溴酸西酞普兰 氢溴酸盐
≥98% (HPLC), powder, serotonin uptake inhibitor
别名:
1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈 氢溴酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H21FN2O · HBr
化学文摘社编号:
分子量:
405.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
261-890-6
MDL number:
产品名称
氢溴酸西酞普兰 氢溴酸盐, ≥98% (HPLC)
InChI
1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
InChI key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
SMILES string
Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
assay
≥98% (HPLC)
form
powder
solubility
chloroform: soluble
methanol: soluble
originator
Forest Labs
storage temp.
2-8°C
Quality Level
Gene Information
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Application
氢溴酸西酞普兰已用于：
- 研究其对小鼠sirt mRNA和哺乳动物Sirtuin(SIRT)表达的影响
- 检测强迫游泳试验大鼠的体温和抗抑郁行为反应
- 5-羟色胺(5-HT)竞争性摄取检测
Biochem/physiol Actions
有效的选择性 5-羟色胺摄取抑制剂 (Ki = 5.4 nM)；抗抑郁药
Features and Benefits
该化合物由 Forest Labs 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，请点击这里 。
General description
西酞普兰是一种双环萘衍生物。它可激发血清素活性，产生抗抑郁作用。西酞普兰可逆转记忆损伤。它可用于治疗强迫症、惊恐症、社交恐怖症和经前烦躁症。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Whole-body hyperthermia and a subthreshold dose of citalopram act synergistically to induce antidepressant-like behavioral responses in adolescent rats
Hale MW, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 79, 162-168 (2017)
Interactions between whole-body heating and citalopram on body temperature, antidepressant-like behaviour, and neurochemistry in adolescent male rats
Hale MW, et al.
Behavioural Brain Research, 359, 428-439 (2019)
Tomoko Soga et al.
Neuropharmacology, 59(1-2), 77-85 (2010-04-13)
Citalopram is the most potent selective serotonin reuptake inhibitor (SSRI) which is used as an antidepressant but causes sexual dysfunction. Whether citalopram induced sexual dysfunction is a result of gonadotropin-releasing hormone (GnRH), kisspeptin or RF-amide related peptide (RFRP) alteration is
Inhibition of the serotonin transporter is altered by metabolites of selective serotonin and norepinephrine reuptake inhibitors and represents a caution to acute or chronic treatment paradigms
Krout D, et al.
ACS Chemical Neuroscience, 8(5), 1011-1018 (2016)
Current Treatments of Obsessive-Compulsive Disorder (2008)
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