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Merck
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主要文件

安全信息

C1805

Sigma-Aldrich

Anti-CD4 antibody, Mouse monoclonal

clone Q4120, purified from hybridoma cell culture

别名:

Anti-CD4 antibody, Mouse monoclonal

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100 TEST
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100 TEST
¥3,579.65

About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

¥3,579.65


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生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

Q4120, monoclonal

表单

buffered aqueous solution

分子量

59 kDa

种属反应性

human

技术

flow cytometry: 5 μL using 1 × 106 cells

同位素/亚型

IgG1

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SAB5500064F1773C7423
species reactivity

human

species reactivity

human (tested)

species reactivity

human

species reactivity

human

conjugate

unconjugated

conjugate

unconjugated

conjugate

FITC conjugate

conjugate

unconjugated

biological source

mouse

biological source

rabbit

biological source

mouse

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

Gene Information

human ... CD4(920)

Gene Information

human ... CD4(920)

Gene Information

human ... CD4(920)

Gene Information

human ... CD8A(925), CD8B(926)

一般描述

Monoclonal Anti-Human CD4 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cell line NS-1 and splenocytes from Balb/c mice immunized with CD4-Transfected mouse T-cell hybridoma, 3DT, followed by CD4+ human T-cell CEM cells. Cluster of differentiation 4 (CD4) human cell surface glycoprotein (59kDa) belongs to the immunoglobulin superfamily. It is expressed on the helper/inducer T cell subset, which is found on the majority of peripheral blood neutrophils, most cortical and mature medullary thymocytes, microglial cells, dendritic cells and on some malignancies of T cell origin.

特异性

Recognizes the CD4. The epitope recognized by the Q4120 clone is located on 1-183 aa and is sensitive to formalin fixation and paraffin embedding. 5th Workshop: code no. CD04.11

免疫原

CD4-transfected mouse T-cell hybridoma, 3DT, followed by CD4+ human T-cell CEM cells.

应用

Monoclonal Anti-CD4 antibody produced in mouse has been used in indirect immunofluorescent staining.

生化/生理作用

Cluster of differentiation 4 (CD4) molecule binds to the major histocompatibility complex (MHC) class II molecules during the interaction of CD4+ T cells with antigen presenting cells or with target cells. It also serves as a high affinity cellular receptor for the GP 120 envelope glycoprotein of the human immunodeficiency virus (HIV-1, HIV-2). The CD4 molecule is involved in the adhesion of T-lymphocytes to target cells, thymic development, transmission of intracellular signals during T cell activation, and binding to polyclonal immunoglobulins. Lower levels of CD4 have been detected in monocytes, macrophages and granulocytes.

目标描述

CD4 is a single chain transmembraneous glycoprotein from the immunoglobulin superfamily. It is expressed on the helper/inducer T subset, on most medullary thymocytes, on microglial, dendritic and on some malignancies of T cell origin. The antigen binds to MHC class II molecules and is associated with p56lck protein tyrosine kinase.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
含少量动物源组分生物产品
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    Wen-Yi Tseng et al.
    PloS one, 8(5), e63963-e63963 (2013-05-24)
    Higher soluble CD4 (sCD4) levels in serum have been detected in patients of infectious and chronic inflammatory diseases. However, how and why sCD4 is produced remains poorly understood. We establish sensitive ELISA and WB assays for sCD4 detection in conditioned
    CD4+ T cells: differentiation and functions
    Luckheeram RV, et al.
    Clinical & Developmental Immunology (2012)
    Jason A LaBonte et al.
    Journal of virology, 77(12), 6645-6659 (2003-05-28)
    T-tropic (X4) and dualtropic (R5X4) human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins kill primary and immortalized CD4(+) CXCR4(+) T cells by mechanisms involving membrane fusion. However, because much of HIV-1 infection in vivo is mediated by M-tropic (R5) viruses
    Down regulation of CD4 expression following isolation and culture of human monocytes
    Graziani-Bowering GM and Filion LG
    Clinical and Diagnostic Laboratory Immunology, 7(2), 182-191 (2000)
    Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4.
    Benkirane M, et al.
    Journal of virology, 69(11), 6898-6903 (1995)

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