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Merck
CN
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文件

安全信息

A0132

Sigma-Aldrich

阿托品

≥99% (TLC), powder

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别名:
(8-甲基-8-氮杂双环[3.2.1]辛-3-基) endo-(+/-)-α-(羟甲基)苯乙酸酯, 莨菪碱, 龙葵碱
经验公式（希尔记法）:
C17H23NO3
CAS号:
51-55-8
分子量:
289.37
Beilstein:
91260
EC 号:
200-104-8
MDL编号:
MFCD00022622
UNSPSC代码:
12352200
PubChem化学物质编号:
24890401
NACRES:
NA.77

检测方案

≥99% (TLC)

形式

powder

颜色

white

溶解性

H2O: 2 mg/mL
dilute aqueous acid: soluble
ethanol: soluble

SMILES字符串

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

InChI key

RKUNBYITZUJHSG-SPUOUPEWSA-N

基因信息

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , LOC730413(730413)
mouse ... Chrm1(12669)
rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Drd2(24318) , Htr1a(24473)

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一般描述

Atropine, a belladonna alkaloid, is an anti-muscarinic drug. It is extracted from Atropa belladonna. Atropine is an anticholinergic agent, which is linked to passive mydriasis. It blocks acetylcholine receptors in brain and has hallucinogenic effects. Atropine eye drops are used to treat uveitis and early amblyopia. It is also used to treat nerve agents.

应用

Atropine has been used to study it′s in vitro cytotoxicity, antiviral and antimicrobial activities. It has also used to antagonize acetylcholine induced K+ current.
Atropine has been used:
  • as a tastant to analyse the bitter taste perception in Drosophila larvae
  • as a muscarinic acetylcholine autoreceptors (mAChRs) antagonist to investigate the involvement of individual mAChR subtypes in the control of synapse elimination
  • to investigate the pathways of serotonin (5-HT) action in zebrafish hearts

生化/生理作用

Atropine is used to treat myopia and ocular axial elongation in Asian children. Small dosage of atropine is used to slow down the heart rate.
位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

重悬

Solutions stable for several days at 4 °C.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

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Atropine for the treatment of childhood myopia
Chua WA, et al.
Ophthalmology, 113(12), 2285-2291 (2006)
Tarascon Pharmacopoeia 2014 Professional Desk Reference Edition (2014)
Muscarinic receptor hyperpolarizes cochlear hair cells of chick by activating Ca (2+)-activated K+ channels.
Shigemoto T, et al.
The Journal of Physiology, 442(1), 669-690 (1991)
The parasympathomimetic activity of atropine and atropine methylbromide
Kottmeier CA, et al.
Anesthesiology, 29(6), 1125-1133 (1968)
Presynaptic muscarinic acetylcholine autoreceptors (M 1, M 2 and M 4 subtypes), adenosine receptors (A 1 and A 2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction
Nadal L, et al.
Molecular Brain, 9(1), 67-67 (2016)
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Chromatograms

application for HPLC

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