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Merck
CN

CHRM2

cholinergic receptor, muscarinic 2

别名:
HM2
物种:
Human CHRM2 (1129), Mouse Chrm2 (243764), Rat Chrm2 (81645), Domestic Rabbit CHRM2 (100342878), naked mole-rat Chrm2 (101714286), chicken CHRM2 (418126), domestic guinea pig Chrm2 (100715343), dog CHRM2 (403858), cow CHRM2 (522170), domestic cat CHRM2 (101099790) ...展开
UniProtKB ID:
P08172, Q4VBK6, Q9P1X9
基因ID:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

货号
说明
物种
A2251
乙酰基-β-氯化甲基胆碱, ≥98% (TLC), powder,
物种
human
O100
氧化震颤素M, solid,
物种
human
C4382
卡巴胆碱, ≥98% (titration), crystalline,
物种
human, mouse, rat

Small Molecule - Antagonist

货号
说明
物种
M105
美索曲明 水合物, ≥97% (NMR), solid,
物种
human
SML1102
达非那新氢溴酸盐 氢溴酸盐, ≥98% (HPLC),
物种
human
1485103
盐酸奥昔布宁, United States Pharmacopeia (USP) Reference Standard,
物种
human
1164200
达非那新氢溴酸盐 氢溴酸盐, United States Pharmacopeia (USP) Reference Standard,
物种
human
O0288000
奥昔布宁 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human

Antibodies

货号
说明
物种反应性
应用
MAB367
抗-毒蕈碱乙酰胆碱受体m2抗体（克隆M2-2-B3）, clone M2-2-B3, Chemicon®, from rat,
物种反应性
human, mammals, monkey, rat
应用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
AB9452
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
物种反应性
human
应用
immunohistochemistry
SAB1405619
Anti-CHRM2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
AB5166
Anti-Muscarinic Acetylcholine Receptor m2 Antibody, Chemicon®, from rabbit,
物种反应性
human, mouse, rat
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
WH0001129M1
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot

Small Molecule - Inhibitor

货号
说明
物种
A8404
盐酸阿米替林 盐酸盐, ≥98% (TLC), powder,
物种
human
D4526
多塞平 盐酸盐, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
物种
human
H1512
氟哌啶醇, powder,
物种
human, rat

Proteins

货号
说明
物种
HTS115M
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
物种
human

esiRNA

货号
说明
物种
EHU120771
MISSION® esiRNA, targeting human CHRM2,
物种
human