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Merck
CN

M104

Sigma-Aldrich

(±)-Muscarine chloride hydrate

≥98% (HPLC)

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别名:
Tetrahydro-4-hydroxy-N,N,N,5-tetramethyl-2-furanmethanammonium chloride hydrate
经验公式(希尔记法):
C9H20ClNO2 · xH2O
CAS号:
分子量:
209.71 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white

溶解性

deionized water: ≥20 mg/mL

储存温度

room temp

SMILES字符串

[Cl-].CC1OC(CC1O)C[N+](C)(C)C

InChI

1S/C9H20NO2.ClH/c1-7-9(11)5-8(12-7)6-10(2,3)4;/h7-9,11H,5-6H2,1-4H3;1H/q+1;/p-1

InChI key

WUFRNEJYZWHXLC-UHFFFAOYSA-M

应用

(±)-Muscarine chloride hydrate may be used:
  • as an acetylcholine receptor agonist in neuronal precursor cell lines PC 12 cells
  • as toxin test compound for paper spray mass spectrometry (PSMS) optimization experiments
  • as a component of quality control(QC) in hydrophilic interaction liquid chromatography-high resolution tandem mass spectrometry (HILIC-HRMS/MS) analysis of human urine samples

生化/生理作用

Muscarine is a potent agonist than acetylcholine and is not susceptible to degradation by cholinesterases. Muscarine administration results in muscle spasm especially in gut, bronchus and uterus.
Muscarinic acetylcholine receptor agonist; originally isolated from Amanita muscaria.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Thomas P Bambauer et al.
Talanta, 204, 677-684 (2019-07-31)
Paper spray mass spectrometry (PSMS) is currently used in different analytical fields, but less effort has been made so far to use PSMS for highly polar compounds. Such analytes usually show poor performance in PSMS due to their high affinity
Chapter 67 - Mushroom Toxins
Puschner B
Veterinary Toxicology, 955-966 (2018)
Two-dimensional surface plasmon resonance imaging system for cellular analysis
Biosensors and Biodetection, 12(1), 47-52 (2017)
P J FRASER
British journal of pharmacology and chemotherapy, 12(1), 47-52 (1957-03-01)
The action of chromatographically pure crystalline muscarine chloride, prepared from Amanita muscaria, has been compared with acetylcholine chloride (ACh) on a number of different organs from a variety of species. Muscarine caused spasm in vivo and in vitro of muscles
Thomas P Bambauer et al.
Talanta, 213, 120847-120847 (2020-03-24)
The analytical proof of a toxic mushroom and/or plant ingestion at an early stage of a suspected intoxication can be crucial for fast therapeutic decision making. Therefore, comprehensive analytical procedures need to be available. This study aimed to develop a

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