所有图片(1)
别名:
UK 88525–04, （3S）-1- [2-（2,3-二氢-5-苯并呋喃基）乙基]-α,α-二苯基-3-吡咯烷乙酰胺 氢溴酸盐
经验公式（希尔记法）:
C28H30N2O2 · HBr
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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +41 to +49°, c = 1 in methylene chloride
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C(N)C([C@H]1CN(CCC2=CC=C(OCC3)C3=C2)CC1)(C4=CC=CC=C4)C5=CC=CC=C5.Br
InChI
1S/C28H30N2O2.BrH/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26;/h1-12,19,25H,13-18,20H2,(H2,29,31);1H/t25-;/m1./s1
InChI key
UQAVIASOPREUIT-VQIWEWKSSA-N
基因信息
human ... CHRM2(1129) , CHRM3(1131)
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一般描述
达非那新是一种毒蕈碱受体拮抗剂。它是一种缓释片剂，含有7.5 mg或15 mg达非那新氢溴酸盐。
应用
氢溴酸达非那新已被用于实验动物注射。
生化/生理作用
氢溴酸达非那新是一种解痉挛毒蕈碱拮抗剂，对阻断M3毒蕈碱乙酰胆碱受体具有选择性。
氢溴酸达非那新是一种解痉挛毒蕈碱拮抗剂，对阻断M3毒蕈碱乙酰胆碱受体具有选择性，M3毒蕈碱乙酰胆碱受体主要负责膀胱肌肉的收缩。 氢溴酸达非那新对M3的亲和力分别比M1和M5高9和12倍，对M3的亲和力比M2和M4分别高59倍。 达非那新在临床上可用于治疗尿失禁和膀胱过度活动症。
特点和优势
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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The Journal of pharmacology and experimental therapeutics, 359(1), 215-229 (2016-08-05)
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods
Ikunobu Muramatsu et al.
Journal of neurochemistry, 149(5), 605-623 (2019-04-11)
Regulation of neurotransmitter release in the central nervous system is complex. Here, we investigated regulatory mechanisms for acetylcholine (ACh) release from cholinergic neurons by performing superfusion experiments with rat striatal segments after labelling the cellular ACh pool with [3 H]choline.
J Di Salvo et al.
The Journal of pharmacology and experimental therapeutics, 360(2), 346-355 (2016-12-15)
Although the physiologic role of muscarinic receptors in bladder function and the therapeutic efficacy of muscarinic antagonists for the treatment of overactive bladder are well established, the role of β
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