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安全信息

P127

Sigma-Aldrich

(+)-Pentazocine

solid

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经验公式（希尔记法）:
C19H27NO
CAS号:
7361-76-4
分子量:
285.42
UNSPSC代码:
12352200
PubChem化学物质编号:
24898179
NACRES:
NA.77

形式

solid

质量水平

100

旋光性

[α]23/D +134.6°, c = 1 in chloroform(lit.)

药品控制

USDEA Schedule IV; Home Office Schedule 3; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)

颜色

white

创始人

Sanofi Aventis

SMILES字符串

[H][C@@]12Cc3ccc(O)cc3[C@@](C)(CCN1C\C=C(\C)C)[C@@H]2C

InChI

1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m1/s1

InChI key

VOKSWYLNZZRQPF-CCKFTAQKSA-N

基因信息

human ... EBP(10682)
rat ... Chrm1(25229) , Chrm2(81645) , Drd2(24318) , Oprm1(25601)

生化/生理作用

σ receptor agonist; active enantiomer of pentazocine.

特点和优势

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

注意

Photosensitive

重悬

A 10 mM solution of (+)-pentazocine is prepared by warming 28.5 mg of (+)-pentazocine free base in 2 mL of 0.1N HCl with shaking or sonication. When all solids have dissolved, the solution is cooled to room temperature and diluted with 10 mL of pH 7 buffer. Solutions should be freshly prepared, since cooling below room temperature may result in precipitation.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Research on the sigma receptor, a binding site associated with drug-induced psychotomimetic behaviors, has been hampered because most sigma agonists also interact with the phencyclidine (PCP) receptor. (+)-Pentazocine, a human psychotogen, is a selective sigma receptor ligand. To demonstrate sigma
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Sigma-1 receptor (σ-1) activation and mitogen-activated protein kinases (MAPKs) have been shown to protect retinal ganglion cells (RGCs) from cell death. The purpose of this study was to determine if σ-1 receptor stimulation with pentazocine could promote neuroprotection under conditions
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