推荐产品
质量水平
检测方案
≥98% (TLC)
形式
powder
mp
171-173 °C (lit.)
溶解性
H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)
储存温度
−20°C
SMILES字符串
[Cl-].CC(C[N+](C)(C)C)OC(C)=O
InChI
1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
InChI key
JHPHVAVFUYTVCL-UHFFFAOYSA-M
基因信息
human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)
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应用
乙酰胆碱的类似物乙酰基-β-甲基胆碱可用作受体激动剂，以研究诸如哮喘相关的气道高反应性等过程。
生化/生理作用
代谢稳定的乙酰胆碱类似物；毒蕈碱激动剂。 其可收缩气道平滑肌的能力可用于评估实验室和临床上的支气管反应性。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
Mina Youssef et al.
The Journal of pharmacology and experimental therapeutics, 373(3), 476-487 (2020-04-11)
Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic
Nizar Naji et al.
Respiratory medicine, 107(4), 503-510 (2013-01-29)
Lung function tests are essential for the diagnosis and management of bronchial asthma. Impulse oscillation (IOS) system is an alternative way to measure lung mechanics for some patients. We investigated the relative sensitivities of IOS, body plethysmography and spirometry in
Martijn C Nawijn et al.
PloS one, 8(2), e55307-e55307 (2013-02-09)
Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction and airway hyperresponsiveness (AHR). The T regulatory (Treg) cell subset is critically important for the regulation of immune responses. Adoptive transfer of Treg cells has been
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