L3771

十二烷基硫酸钠

Name: 十二烷基硫酸钠
Brand: SIGMA

BioReagent, suitable for electrophoresis, Molecular Biology, ≥98.5% (GC)

别名:

月桂基硫酸盐钠盐, 月桂基硫酸钠, SDS, 十二烷基硫酸盐钠盐, 十二烷基硫酸钠

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线性分子式:

CH₃(CH₂)₁₁OSO₃Na

化学文摘社编号:

151-21-3

分子量:

288.38

NACRES:

NB.22

PubChem Substance ID:

24896351

eCl@ss:

39093306

UNSPSC Code:

12161902

EC Number:

205-788-1

MDL number:

MFCD00036175

Beilstein/REAXYS Number:

3599286

主要文件

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InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

biological source

synthetic

grade

Molecular Biology

description

anionic

product line

BioReagent

assay

≥98.5% (GC)

form

powder

mol wt

micellar 18,000

Quality Level

200

foreign activity

DNase, RNase, none detected

greener alternative category

Aligned

storage temp.

room temp

suitability

suitable for electrophoresis

greener alternative product characteristics

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

aggregation number

technique(s)

electrophoresis: suitable

impurities

≤2.0% water (Karl Fischer)

CMC

7-10 mM (20-25°C)

mp

204-207 °C (lit.)

transition temp

cloud point >100 °C

solubility

water: soluble

density

1.03 g/cm³ at 20 °C (68 °F)

anion traces

chloride (Cl^-): ≤500 ppm, phosphate (PO₄^3-): ≤10 ppm

cation traces

heavy metals (as Pb): ≤10 ppm

absorption

≤0.1 at 260 at 3%, ≤0.1 at 280 at 3%

HLB

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General description

十二烷基硫酸钠（SDS）也称月桂基硫酸钠，它是一种阴离子表面活性剂，广泛应用于各种科学应用，特别是分子生物学、生物化学和细胞生物学研究。它的功效来源于两性分子特性，这种特性使其可以同时与疏水和亲水分子相互作用。SDS是一种可以使蛋白质增溶和变性的多功能去污剂，这种特性使其成为蛋白质提取和纯化实验中的基本工具。在SDS-PAGE电泳中，通过破坏蛋白质结构，SDS有助于根据分子量进行蛋白质分离。

除了蛋白质分析以外，SDS的应用还包括脂质的电泳分离，从而使研究人员能够对这些重要的细胞成分进行研究和表征。此外，各种杂交和分子生物学技术中也用到了SDS，这体现了它在各种研究领域中的多功能性。SDS在离子和非离子条件下的功效进一步扩展了其用途，使其适用于各种实验环境和要求。它能够通过结合肽链并产生负电荷来裂解蛋白，从而有效消除了凝胶分离中蛋白质形状这一影响因素，确保了准确的蛋白质尺寸测定。

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is used as a surfactant to enhance catalysis. Click here for more information.

Application

十二烷基硫酸钠已用于：

染色体免疫沉淀
SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）
作为用于免疫印迹的放射免疫沉淀检测缓冲液的一种组分

用于增溶和蛋白质变性，适用于PAGE变性应用。大多数蛋白质以1.4 g SDS/g 蛋白质的比例结合SDS。相对于结合的SDS自带的总负电荷，蛋白质固有电荷几乎可忽略不计。每种蛋白质的质荷比基本相同，且基于分子大小在凝胶中迁移。

阴离子洗涤剂

Features and Benefits

用于分子生物学和生物化学研究的多功能表面活性剂
适用于电泳应用
经测试证实重金属污染浓度低，从而确保其适用于各种应用。

Analysis Note

针对用于变性聚丙烯酰胺凝胶电泳进行了测试。

Other Notes

如需了解生化试剂系列的更多信息，请填写此表。

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

pictograms

GHS02,GHS05,GHS07

signalword

Danger

hcodes

H228,H302 + H332,H315,H318,H335,H412

pcodes

P210 - P273 - P280 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

4.1B - Flammable solid hazardous materials

wgk

WGK 2

flash_point_f

338.0 °F

flash_point_c

170 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice.

Kazuya Ishikawa et al.

Nature communications, 5, 5430-5430 (2014-11-13)

Pathogen effector proteins are delivered to host cells to suppress plant immunity. However, the mechanisms by which effector proteins function are largely unknown. Here we show that expression of XopP(Xoo), an effector of rice pathogen Xanthomonas oryzae pv. oryzae, in

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.

Shane Stegeman et al.

Endocrine-related cancer, 22(2), 265-276 (2015-02-12)

The oncogene MDM4, also known as MDMX or HDMX, contributes to cancer susceptibility and progression through its capacity to negatively regulate a range of genes with tumour-suppressive functions. As part of a recent genome-wide association study it was determined that

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.

S Bavamian et al.

Molecular psychiatry, 20(5), 573-584 (2015-01-28)

Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we hypothesized that microRNAs (miRNAs) might be of importance for BD. Here we show that levels of miR-34a, which

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies.

Satoshi Fukuyama et al.

Nature communications, 6, 6600-6600 (2015-03-26)

Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza

Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling.

Tadayoshi Hayata et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(2), 318-329 (2014-08-27)

Transforming growth factor (TGF)-β signaling plays critical roles during skeletal development and its excessive signaling causes genetic diseases of connective tissues including Marfan syndrome and acromelic dysplasia. However, the mechanisms underlying prevention of excessive TGF-β signaling in skeletogenesis remain unclear.

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实验方案

Stripping and Reprobing Western Blotting Membranes

This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

Plasmid DNA Preparation

Preparation of Plasmid DNA by Alkaline Lysis with SDS: Maxipreparation between Cold Spring Harbor Laboratory Press and our research team.

Hand-casting gels for PAGE and SDS-PAGE using mPAGE® TurboMix Bis-Tris Gel Casting Kits

Simplify your SDS-PAGE gel preparation with our pre-mixed solutions and protocols to achieve precise protein separation.

使用mPAGE® TurboMix Bis-Tris制胶试剂盒手动灌制PAGE和SDS-PAGE凝胶

聚丙烯酰胺凝胶化学性质概述以及使用mPAGE® TurboMix Bis-Tris制胶试剂盒手动灌注聚丙烯酰胺凝胶的详细说明

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十二烷基硫酸钠

BioReagent, suitable for electrophoresis, Molecular Biology, ≥98.5% (GC)

选择尺寸

关于此项目

主要文件

属性

InChI

InChI key

SMILES string

biological source

grade

description

product line

assay

form

mol wt

Quality Level

foreign activity

greener alternative category

storage temp.

suitability

greener alternative product characteristics

sustainability

aggregation number

technique(s)

impurities

CMC

mp

transition temp

solubility

density

anion traces

cation traces

absorption

HLB

相关类别

说明

General description

Application

Features and Benefits

Analysis Note

Other Notes

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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