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Y0000079

盐酸阿替卡因

Name: 盐酸阿替卡因
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride, Carticaine chlorhydrate, Carticaine hydrochloride

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About This Item

经验公式（希尔记法）:

C₁₃H₂₀N₂O₃S · HCl

CAS号:

23964-57-0

分子量:

320.84

MDL编号:

MFCD00190157

UNSPSC代码:

41116107

PubChem化学物质编号:

329830834

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

articaine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

CC1=CSC(C(OC)=O)=C1NC(C(C)NCCC)=O.Cl

InChI

1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H

InChI key

GDWDBGSWGNEMGJ-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Articaine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Articaine is an amide local anesthetic widely used in dentistry. Articaine acts by inhibition of nerve impulse conduction by blockade of sodium channels.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1042929

1042930

1042962

PHR1882

阿替卡因, Pharmaceutical Secondary Standard; Certified Reference Material

07356

4-Methyl-N-propyl-3-[[(2RS)-2-(propylamino)propanoyl]amino]thiophene-2-carboxamide hydrochloride, reference material

07380

1-Methylethyl 4-methyl-3-[[(2RS)-2-(propylamino)-propanoyl]amino]thiophene-2-carboxylate hydrochloride, reference material

CRM69760

3-[[(2RS)-2-溴丙酰基]氨基]-4-甲基噻吩-2-羧酸甲酯, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

CRM72531

Methyl 3-[[(2RS)-2-(ethylamino)propanoyl]amino]-4-methylthiophene-2- carboxylate hydrochloride, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

象形图

GHS07

警示用语：

Warning

危险声明

H315,H319,H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number

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Infiltration anesthesia for extraction of the mandibular molars.

Khalid E El-Kholey

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(10), 1658-1658 (2013-09-18)

Profound anesthesia for mandibular molars by buccal infiltration has been tried in recent years, with promising results. This prospective, randomized, single-blinded, crossover study investigated the clinical anesthetic efficacy obtained with 1:100,000 epinephrine plus 4% articaine (A100) 1.8 versus 3.6 mL

Chloroprocaine 40 mg produces shorter spinal block than articaine 40 mg in day-case knee arthroscopy patients.

J G Förster et al.

Acta anaesthesiologica Scandinavica, 57(7), 911-919 (2013-03-26)

Articaine and chloroprocaine have recently gained interest as short-acting spinal anaesthetics. Based on previous work comparing articaine 60 mg with chloroprocaine 40 mg, we hypothesised that articaine 40 mg and chloroprocaine 40 mg would produce similar spinal anaesthesa regarding block onset, maximal spread, and

Aspiration in intra-ligamental anaesthesia of lower first molar teeth: a pilot study.

Denis Medvedev et al.

Oral health and dental management, 11(3), 95-99 (2012-09-15)

This pilot prospective, randomised, crossover study of positive aspiration frequency in intra-ligamental anaesthesia (ILA) was conducted with the following aims: (1) to determine the frequency of positive aspiration of blood after the administration of ILA at lower first molars, and

The effectiveness of an additional lingual infiltration in the pulpal anesthesia of mandibular teeth: a systematic review.

Lei Dou et al.

Quintessence international (Berlin, Germany : 1985), 44(5), 457-464 (2013-03-13)

The aim of this systematic review is to investigate the effect of an additional lingual infiltration on the pulpal anesthesia of mandibular teeth. Prospective clinical trials were searched from Medline, EMBASE, Cochrane Library, Pubmed, SCI, and the China National Knowledge

Articaine use in children: a review.

R Leith et al.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 13(6), 293-296 (2012-12-14)

Lidocaine has been considered the gold standard for local analgesia agents in dentistry for years. Articaine is now widely used but there has been a reluctance to use it in children. Compared with lidocaine, articaine is 1.5 times as potent

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