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Y0000079

盐酸阿替卡因

European Pharmacopoeia (EP) Reference Standard

别名:

4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride, Carticaine chlorhydrate, Carticaine hydrochloride

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About This Item

经验公式（希尔记法）:
C13H20N2O3S · HCl
CAS号:
23964-57-0
分子量:
320.84
MDL编号:
MFCD00190157
UNSPSC代码:
41116107
PubChem化学物质编号:
329830834
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

articaine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CC1=CSC(C(OC)=O)=C1NC(C(C)NCCC)=O.Cl

InChI

1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H

InChI key

GDWDBGSWGNEMGJ-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Articaine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Articaine is an amide local anesthetic widely used in dentistry. Articaine acts by inhibition of nerve impulse conduction by blockade of sodium channels.
Articaine is an amide local anesthetic; sodium channel blocker.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

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Articaine, United States Pharmacopeia (USP) Reference Standard

1042929

Articaine Related Compound A, United States Pharmacopeia (USP) Reference Standard

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Articaine Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Articaine Related Compound E, United States Pharmacopeia (USP) Reference Standard

PHR1882

阿替卡因, Pharmaceutical Secondary Standard; Certified Reference Material

07356

4-Methyl-N-propyl-3-[[(2RS)-2-(propylamino)propanoyl]amino]thiophene-2-carboxamide hydrochloride, reference material

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1-Methylethyl 4-methyl-3-[[(2RS)-2-(propylamino)-propanoyl]amino]thiophene-2-carboxylate hydrochloride, reference material

CRM69760

3-[[(2RS)-2-溴丙酰基]氨基]-4-甲基噻吩-2-羧酸甲酯, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

CRM72531

Methyl 3-[[(2RS)-2-(ethylamino)propanoyl]amino]-4-methylthiophene-2- carboxylate hydrochloride, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sepideh Amjad-Iranagh et al.
Journal of molecular modeling, 19(9), 3831-3842 (2013-06-27)
Articaine, as a local anesthetic drug has been simulated in neutral and charged forms, and its interaction with the dimyristoylphosphatidylcholine (DMPC) lipid bilayer membrane is investigated by molecular dynamics simulation using GROMACS software. In order to obtain the optimum location
Kagan Degerliyurt et al.
Implant dentistry, 22(3), 289-294 (2013-05-08)
Although epinephrine is one of the most commonly used vasoconstrictor in association with local anesthesia in dentistry, systemic effects of topical admission of epinephrine for sinus augmentation have not been investigated yet. The purpose of this study was to reveal
Urticaria due to an intradermal test with articaine hydrochloride.
G Davila-Fernández et al.
Journal of investigational allergology & clinical immunology, 22(5), 373-374 (2012-10-30)
R Leith et al.
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 13(6), 293-296 (2012-12-14)
Lidocaine has been considered the gold standard for local analgesia agents in dentistry for years. Articaine is now widely used but there has been a reluctance to use it in children. Compared with lidocaine, articaine is 1.5 times as potent
Anna Smothers Dressman et al.
Journal of endodontics, 39(3), 313-318 (2013-02-14)
The authors conducted a prospective, randomized, single-blind study to determine the degree of pulpal anesthesia obtained with a primary infiltration of 1 cartridge of articaine in the incisive/mental nerve region of the mandibular second premolar and to determine the anesthetic
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