等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. B1212000
traceable to USP 1083008
蒸汽密度
6.2 (vs air)
API类
butylhydroxyanisole
CofA
current certificate can be downloaded
自燃温度
599 °F
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
58-60 °C (lit.)
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-30°C
InChI
1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3
InChI key
MRBKEAMVRSLQPH-UHFFFAOYSA-N
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一般描述
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
应用
丁基羟基苯甲醚(BHA)可用作参考标准品，用于通过分光光度测定法测定药膏中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
分析说明
这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。
其他说明
该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。
附注
要查看该材料的分析证书示例，请在下面的栏位中输入LRAB3751。这只是一个示例证书，可能不是您收到的批次。
Determination of miconazole in pharmaceutical creams using internal standard and second derivative spectrophotometry.
Wrobel K, et al.
Journal of Pharmaceutical and Biomedical Analysis, 20(1-2), 99-105 (1999)
In vivo studies on butylated hydroxyanisole.
F Iverson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(9-10), 993-997 (1999-10-29)
[Modification of the processes of chemical mutagenesis and carcinogenesis by synthetic phenol antioxidants such as butylated hydroxyanisole].
K Demkowicz-Dobrzański et al.
Postepy biochemii, 38(1), 37-42 (1992-01-01)
F Iverson
Cancer letters, 93(1), 49-54 (1995-06-29)
Synthetic phenolic antioxidants have been added to foods for decades to retard the autooxidation of lipid that leads to rancidity. The major antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), are used in foods world wide. Recent studies suggest that
H C Grice
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(8), 717-723 (1988-08-01)
Butylated hydroxyanisole (BHA) induces tumours of the squamous epithelium of the forestomach of rodents, but not at other sites. Although humans do not have squamous epithelium in their stomach the likelihood that BHA will induce tumours of the squamous epithelium
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