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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1564006
API类
procaine
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
155-156 °C (lit.)
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-30°C
SMILES字符串
Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1
InChI
1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
InChI key
HCBIBCJNVBAKAB-UHFFFAOYSA-N
基因信息
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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一般描述
Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Procaine hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrochemical, chemiluminescence, and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
附注
To see an example of a Certificate of Analysis for this material enter LRAA7177 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Batch and flow-injection spectrophotometric determination of procaine HCl in pharmaceutical preparations via using diazotization and coupling reaction
Baghdad Science Journal, 9(3), 521-531 (2012)
Effect of the presence of ?-cyclodextrin on the solution behavior of procaine hydrochloride. Spectroscopic and thermodynamic studies
Langmuir, 16(4), 1557-1565 (2000)
Induction of alkaline phosphatase in Escherichia coli: effect of procaine hydrochloride.
Journal of Bacteriology, 131(2), 431-437 (1977)
Improved therapeutic index of cisplatin by procaine hydrochloride
Journal of the National Cancer Institute, 82(8), 677-684 (1990)
Colorimetric Determination of Procaine hydrochloride in Pharmaceutical Preparations using Diazotization Coupling Reactions
International Journal of PharmTech Research, 8(1), 1042-1042 (2015)
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