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Merck
CN

PHR1161

Supelco

普鲁卡因 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
4-氨基苯甲酸-2-二乙氨乙酯, 奴佛卡因 盐酸盐, 对氨基苯甲酸二乙氨乙酯 盐酸盐
线性分子式:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
CAS号:
分子量:
272.77
Beilstein:
3917802
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1564006

API类

procaine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

155-156 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

InChI key

HCBIBCJNVBAKAB-UHFFFAOYSA-N

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一般描述

Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Procaine hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrochemical, chemiluminescence, and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAA7177 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Batch and flow-injection spectrophotometric determination of procaine HCl in pharmaceutical preparations via using diazotization and coupling reaction
Al-Ward HS, et al.
Baghdad Science Journal, 9(3), 521-531 (2012)
Effect of the presence of ?-cyclodextrin on the solution behavior of procaine hydrochloride. Spectroscopic and thermodynamic studies
Merino C, et al.
Langmuir, 16(4), 1557-1565 (2000)
Induction of alkaline phosphatase in Escherichia coli: effect of procaine hydrochloride.
Tribhuwan RC and Pradhan DS
Journal of Bacteriology, 131(2), 431-437 (1977)
Improved therapeutic index of cisplatin by procaine hydrochloride
Esposito M, et al.
Journal of the National Cancer Institute, 82(8), 677-684 (1990)
Colorimetric Determination of Procaine hydrochloride in Pharmaceutical Preparations using Diazotization Coupling Reactions
Al-Uzri WA and Al-Heeti MI
International Journal of PharmTech Research, 8(1), 1042-1042 (2015)

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